机构：[1]Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.血管外科首都医科大学宣武医院[2]Institute of Vascular Surgery, Capital Medical University, Beijing, China.[3]Section of Vascular Surgery, Vascular Biology and Therapeutics, Yale University, New Haven, CT, USA.[4]Yale University, New Haven, CT, USA.[5]Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Hunan, China.
Over the last decade, many studies have indicated a therapeutic potential for treating diabetic lower extremity ulcers with autologous stem cells. The aim of the current study was to conduct a systematic review and meta-analysis of the treatment of diabetic foot ulcers (DFUs) with autologous stem cells. The search strategy included the Pubmed, EMBASE, Web of Science, and Cochrane's Library databases. The endpoint measured was the healing of DFUs. Six eligible randomized controlled trial (RCT) studies were screened from related published studies and reviewed for meta-analysis. The overall meta-analysis showed that stem cell administration was significantly favorable for healing diabetic ulcers (mean difference (MD) 0.52, 95% confidence interval (CI) 0.38-0.65; p < 0.00001). Subgroup analyses indicated that stem cells seemed to exert similar beneficial effects on patients with ulcer size >= 5 cm(2) (MD 0.76, 95% CI 0.55-0.97; p < 0.00001) and < 5 cm(2) (MD 0.43, 95% CI 0.31-0.54; p < 0.00001). Furthermore, stem cells had similar effects on patients aged >= 70 years (MD 0.61, 95% CI 0.14-1.08; p = 0.01) and < 70 years (MD 0.47, 95% CI 0.35-0.58; p < 0.00001). This systematic review and meta-analysis suggests a promising role for stem cells in DFU treatment. This review will pave the way to further study on the long-term effects of stem cell-based therapy and large-scale RCTs.
基金：
grant no. XMLX201610 from the Beijing Municipal Administration of Hospitals Clinical Technology Innovation Program,
grant no. DFL20150801 from the Beijing Municipal Administration of Hospitals Climbing Talent Training Program,
grant no. 2016000020124G108 from the Beijing Outstanding Talents Project,
the Beijing Municipal Science and Technology Commission Clinical features Applied Research Projects Z141107002514063.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|2 区医学
小类|2 区医学：研究与实验3 区细胞生物学
最新[2023]版：
大类|2 区医学
小类|2 区细胞与组织工程2 区细胞生物学2 区医学：研究与实验
JCR分区：
出版当年[2015]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ2CELL BIOLOGY
最新[2023]版：
Q1CELL & TISSUE ENGINEERINGQ1CELL BIOLOGYQ1MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.[2]Institute of Vascular Surgery, Capital Medical University, Beijing, China.
通讯作者：
通讯机构：[1]Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.[2]Institute of Vascular Surgery, Capital Medical University, Beijing, China.[5]Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Hunan, China.
推荐引用方式(GB/T 7714)：
Jianming Guo,Alan Dardik,Kacey Fang,et al.Meta-analysis on the treatment of diabetic foot ulcers with autologous stem cells[J].STEM CELL RESEARCH & THERAPY.2017,8(1):228.doi:10.1186/s13287-017-0683-2.
APA：
Jianming Guo,Alan Dardik,Kacey Fang,Ruixue Huang&Yongquan Gu.(2017).Meta-analysis on the treatment of diabetic foot ulcers with autologous stem cells.STEM CELL RESEARCH & THERAPY,8,(1)
MLA：
Jianming Guo,et al."Meta-analysis on the treatment of diabetic foot ulcers with autologous stem cells".STEM CELL RESEARCH & THERAPY 8..1(2017):228
医学