机构：[1]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[2]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[3]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.[4]Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, 100069, China.[5]Center of Parkinson Disease, Beijing Institute for Brain Disorders, Beijing, 100069, China.[6]Beijing Key Laboratory on Parkinson Disease, Beijing, 100053, China.[7]Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.[8]Department of Neurobiology, Beijing Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.首都医科大学宣武医院[9]Department of Physiology, Capital Medical University, Beijing, 100069, China.
Relationships among clinical characteristics, iron metabolism and neurotransmitters in Parkinson disease (PD) patients with restless legs syndrome (RLS) remains unclear. We divided 218 patients into PD with and with no RLS (PD-RLS and PD-NRLS) groups by RLS-rating scale (RLS-RS) score. Motor and non-motor symptoms were rated by related scales. Iron and related proteins, and neurotransmitters in cerebrospinal fluid (CSF) and serum were measured. PD-RLS frequency was 40.37%. PD-RLS group had longer duration, higher stage and scores of motor symptoms, depression, anxiety, sleep disorders, fatigue and apathy, and increased transferrin and decreased iron, ferritin, dopamine (DA) and 5-hydroxytryptamine (5-HT) in CSF. In CSF of PD-RLS group, RLS-RS score was positively correlated with transferrin level and negatively correlated with iron and ferritin levels; RLS-RS score was negatively correlated with DA and 5-HT levels; transferrin level was negatively correlated with DA and 5-HT levels, and ferritin level was positively correlated with DA level. In serum, PD-RLS group had decreased iron and transferrin levels, which were negatively correlated with RLS-RS score. PD-RLS was common and severer in motor and some non-motor symptoms. Iron deficiency induced by its metabolism dysfunctions in peripheral and central systems might cause PD-RLS through decreasing brain DA and 5-HT.
基金：
the National Key Plan for Scientific Research and Development of China (2016YFC1306000, 2016YFC1306300),
the National Natural Science Foundation of China (81571229, 81071015,30770745),
Key Project of National Natural Science Foundation of China (81030062),
the Key Project of Natural Science Foundation of Beijing, China (B) (kz201610025030),
the Key Project of Natural Science Foundation of Beijing, China (4161004, kz200910025001),
Natural Science Foundation of Beijing, China (7082032),
National Key Basic Research Program of China (2011CB504100),
Important National Science & Technology Specific Projects (2011ZX09102–003–01),
National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2013BAI09B03),
Project of Beijing Institute for Brain Disorders (BIBD-PXM2013_014226_07_000084),
High Level Technical Personnel Training Project of Beijing Health System, China (2009-3-26),
Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality (IDHT20140514),
Capital Clinical Characteristic Application Research (Z12110700100000, Z121107001012161),
Beijing Healthcare Research Project,China (JING-15-2, JING-15-3),
Excellent Personnel Training Project of Beijing, China (20071D0300400076),
Basic-Clinical Research Cooperation Funding of Capital Medical University, China (2015-JL-PT-X04, 10JL49, 14JL15),
Youth Research Funding, Beijing Tiantan Hospital, Capital Medical University, China (2014-YQN-YS-18, 2015-YQN-15, 2015-YQN-05, 2015-YQN-14, 2015-YQN-17).
第一作者机构：[1]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
通讯作者：
通讯机构：[1]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[2]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[3]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.[4]Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, 100069, China.[5]Center of Parkinson Disease, Beijing Institute for Brain Disorders, Beijing, 100069, China.[6]Beijing Key Laboratory on Parkinson Disease, Beijing, 100053, China.
推荐引用方式(GB/T 7714)：
Ying-Shan Piao,Teng-Hong Lian,Yang Hu,et al.Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters[J].SCIENTIFIC REPORTS.2017,7(1):10547.doi:10.1038/s41598-017-10593-7.
APA：
Ying-Shan Piao,Teng-Hong Lian,Yang Hu,Li-Jun Zuo,Peng Guo...&Wei Zhang.(2017).Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters.SCIENTIFIC REPORTS,7,(1)
MLA：
Ying-Shan Piao,et al."Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters".SCIENTIFIC REPORTS 7..1(2017):10547
