机构：[a]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China[b]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China[c]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China放射科首都医科大学宣武医院[d]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China[e]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[f]Lifespan Connectome and Behavior Team, Institute of Psychology, Chinese Academy of Sciences, Beijing, China[g]Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
Alterations in both local and remote connectivity were reported in amnestic mild cognitive impairment aMCI) patients but rarely in the same group of patients. In the present study, we employed a novel resting-state functional magnetic resonance imaging (rfMRI) connectome index, regional functional homogeneity on the 2-dimensional cortical surface, to detect full-cortex vertex-wise changes of the local rfMRI connectivity in 32 aMCI patients compared with 40 healthy controls. We further used the seedbased functional connectivity to explore the remote rfMRI connectivity in aMCI. The results revealed significantly lower local connectivity in the default network and higher local connectivity in the somatomotor network in aMCI patients. Abnormal remote connectivity relevant to local connectivity was primarily detectable within the default network (decrease) and in the somatomotor and attention networks (increase). The abnormalities in the remote (not local) default network connectivity were significantly associated with episodic memory performance in patients. These distance-related connectivity profiles illustrated a dysfunctional pattern in aMCI, which extended our knowledge of this pathological aging process. (C) 2017 Elsevier Inc. All rights reserved.
基金：
National Basic Research Program (973 Program) (2015CB351702),
Chinese Academy of Sciences Youth Innovation Promotion Association (2016084),
National Natural Science Foundation of China (81220108014, 81471740, 31000465,31371007)
Beijing Municipal Science & Technology Commission (Z161100000216152).
第一作者机构：[a]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China[b]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, PR China.[*2]Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, PR China
推荐引用方式(GB/T 7714)：
Yi-Wen Zhang,Zhi-Lian Zhao,Zhigang Qi,et al.Local-to-remote cortical connectivity in amnestic mild cognitive impairment[J].NEUROBIOLOGY OF AGING.2017,56:138-149.doi:10.1016/j.neurobiolaging.2017.04.016.
APA：
Yi-Wen Zhang,Zhi-Lian Zhao,Zhigang Qi,Yang Hu,Yin-Shan Wang...&Xi-Nian Zuo.(2017).Local-to-remote cortical connectivity in amnestic mild cognitive impairment.NEUROBIOLOGY OF AGING,56,
MLA：
Yi-Wen Zhang,et al."Local-to-remote cortical connectivity in amnestic mild cognitive impairment".NEUROBIOLOGY OF AGING 56.(2017):138-149
