机构：[1]Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.老年医学科首都医科大学宣武医院[2]Beijing Key Laboratory on Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China.[3]Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Parkinson's disease (PD) patients have difficulty in performing a dual-task. It has been suggested that the cerebellum is important in dual-tasking. We used functional MRI to investigate the role of the cerebellum in performing a dual motor and cognitive task in PD patients. We have examined whether there are any areas additionally activated for dual-task performance, and compared the neural activity and functional connectivity pattern in the cerebellum between PD patients and healthy controls. We found that the right cerebellar vermis and left lobule V of cerebellar anterior lobe were additionally activated for dual-task performance in healthy controls and for motor task in PD patients. We didn't find any cerebellar regions additionally activated while performing dual-task in PD patients. In addition, the right cerebellar vermis had enhanced connectivity with motor and cognitive associated networks in PD patients. PD patients have limited cerebellar resources that are already utilized for single tasks and, for dual tasks, cannot augment as necessary in order to integrate motor and cognitive networks.
基金：
the National Science Foundation of China (81571228).
第一作者机构：[1]Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.[2]Beijing Key Laboratory on Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China.
通讯作者：
通讯机构：[1]Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.[2]Beijing Key Laboratory on Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China.
推荐引用方式(GB/T 7714)：
Linlin Gao,Jiarong Zhang,Yanan Hou,et al.The cerebellum in dual-task performance in Parkinson's disease[J].SCIENTIFIC REPORTS.2017,7:doi:10.1038/srep45662.
APA：
Linlin Gao,Jiarong Zhang,Yanan Hou,Mark Hallett,Piu Chan&Tao Wu.(2017).The cerebellum in dual-task performance in Parkinson's disease.SCIENTIFIC REPORTS,7,
MLA：
Linlin Gao,et al."The cerebellum in dual-task performance in Parkinson's disease".SCIENTIFIC REPORTS 7.(2017)
