机构：[a]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[b]Department of Neurology, Tangshan Gongren Hospital, Tangshan, Hebei Province, China[c]School of Biomedical Engineering, Capital Medical University, Beijing, China[d]XiangYa School of Medicine, Central South University, Changsha, Hunan Province, China[e]Department of Rehabilitation, XuanWu Hospital of Capital Medical University, Beijing, China康复医学科首都医科大学宣武医院[f]The StateKey Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China[g]Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA[h]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[i]National Clinical Research Center for Geriatric Disorders, Beijing, China[j]PKU Care Rehabilitation Hospital, Beijing, China[k]Beijing Institute of Geriatrics, Beijing, China
Background: Depression is a potential marker of preclinical Alzheimer's disease (AD). However, little is known about the abnormal characteristics revealed by resting-state functional magnetic resonance imaging (rs-fMRI) in mild cognitive impairment (MCI) subjects with depressive symptoms (MCI-d). Objective: The study was to examine whether abnormalities in amplitudes of low-frequency oscillation occurred in MCI-d and tried to find the possible spectrum showed higher recognition ability to the diagnosis by utilizing functional MRI (fMRI). Methods: The amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) within full frequency (0.01-0.1 Hz), slow-5 (0.01-0.027 Hz), and slow-4 (0.027-0.073 Hz) were computed using resting-state fMRI data of 27 MCI without depressive symptoms, 19 MCI-d, and 32 well-matched healthy controls (HC). Analysis of covariance was performed on ALFF and fALFF among MCI, MCI-d, and HC groups. Results: Several brain regions showed significant differences in ALFF and fALFF within full frequency, slow-5, and slow-4 bands among three groups. Importantly, receiver operating characteristic analysis revealed that the ALFF values in the full frequency band in the left parahippocampal gyrus and the left precuneus, Slow 5 value in ALFF in the left inferior frontal gyrus, and Slow 4 value in ALFF in the left precuneus could effectively differentiate MCI-d from MCI patients. Conclusion: In this study, we found that several changes in special brain regions are associated with MCI and MCI-d patients. And the differences depend on the studied frequency bands of rs-fMRI data. The affective network and the default-mode network might be damaged simultaneously in MCI-d patients.
基金：
the National Key Research and Development Program of China (No. 2016YFC1306300),
National Natural Science Foundation of China (No. 31371007, 81430037,61633018),
Beijing Natural Science Foundation (No.7161009, 7174282),
Hundred, Thousand, and Ten Thousand Talents Project of Beijing (No. 2010-005),
Beijing Municipal Science & Technology Commission (No. Z161100002616020),
Fundamental and Clinical Cooperative Research Program of Capital Medical University (No. 16JL-L08, 15JL18),
Beijing Municipal Science & Technology Commission (No.Z131100006813022),
Health and Family Planning Commission of Shunyi District Beijing,
CSA Key Laboratory of Behavioral Science, Institute of Psychology,
Project of Science and Technology office of Hebei Province (No. 162777169).
第一作者机构：[a]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China[b]Department of Neurology, Tangshan Gongren Hospital, Tangshan, Hebei Province, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, XuanWu Hospital of Capital Medical University, No. 45, Changchun Street, Xicheng district, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Yuxia Li,Bin Jing,Han Liu,et al.Frequency-Dependent Changes in the Amplitude of Low-Frequency Fluctuations in Mild Cognitive Impairment with Mild Depression[J].JOURNAL OF ALZHEIMERS DISEASE.2017,58(4):1175-1187.doi:10.3233/JAD-161282.
APA：
Yuxia Li,Bin Jing,Han Liu,Yifan Li,Xuan Gao...&Ying Han.(2017).Frequency-Dependent Changes in the Amplitude of Low-Frequency Fluctuations in Mild Cognitive Impairment with Mild Depression.JOURNAL OF ALZHEIMERS DISEASE,58,(4)
MLA：
Yuxia Li,et al."Frequency-Dependent Changes in the Amplitude of Low-Frequency Fluctuations in Mild Cognitive Impairment with Mild Depression".JOURNAL OF ALZHEIMERS DISEASE 58..4(2017):1175-1187
