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Serotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease

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机构： [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. [2]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. [3]Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. [4]Department of Neurobiology and Physiology, Capital Medical University, Beijing, 100069, China. [5]Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, 100069, China. [6]Beijing Key Laboratory on Parkinson Disease, Beijing, 100053, China. [7]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. [8]Department of Neurobiology, Beijing Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. [9]Department of Neurobiology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China. [10]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.

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摘要：

Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of mental fatigue involving serotonergic dysfunction and abnormal iron metabolism are still unknown. Therefore, we evaluated the fatigue symptoms, classified PD patients into fatigue group and non-fatigue group, and detected the levels of serotonin, iron and related proteins in CSF and serum. In CSF, 5-HT level is significantly decreased and the levels of iron and transferrin are dramatically increased in fatigue group. In fatigue group, mental fatigue score is negatively correlated with 5-HT level in CSF, and positively correlated with the scores of depression and excessive daytime sleepiness, and disease duration, also, mental fatigue is positively correlated with the levels of iron and transferrin in CSF. Transferrin level is negatively correlated with 5-HT level in CSF. In serum, the levels of 5-HT and transferrin are markedly decreased in fatigue group; mental fatigue score exhibits a negative correlation with 5-HT level. Thus serotonin dysfunction in both central and peripheral systems may be correlated with mental fatigue through abnormal iron metabolism. Depression, excessive daytime sleepiness and disease duration were the risk factors for mental fatigue of PD.

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出版当年[2015]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

最新[2023]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

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出版当年[2014]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.8 最新[2023版] 4.3 最新五年平均 5.578 出版当年[2014版] 5.597 出版当年五年平均 5.078 出版前一年[2013版] 5.228 出版后一年[2015版]

第一作者：

第一作者机构： [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.

通讯作者：

通讯机构： [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. [2]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. [5]Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, 100069, China. [6]Beijing Key Laboratory on Parkinson Disease, Beijing, 100053, China. [7]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. [10]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.

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