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Intermittent theta burst stimulation modulates resting-state functional connectivity in the attention network and promotes behavioral recovery in patients with visual spatial neglect

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机构: [1]Department of Rehabilitation, Xuanwu Hospital Capital Medical University, Beijing, People’s Republic of China
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关键词: dorsal attention network intermittent theta burst stimulation left dorsal lateral prefrontal cortex resting-state functional connectivity ventral attention network visual spatial neglect

摘要:
Functional connectivity changes in the attention network are viewed as a physiological signature of visual spatial neglect (VSN). The left dorsal lateral prefrontal cortex (LDLPFC) is known to initiate and monitor top-down attentional control and dynamically adjust behavioral performance. This study aimed to investigate whether increasing the activity of the LDLPFC through intermittent. burst stimulation (iTBS) could modulate the resting-state functional connectivity in the attention network and facilitate recovery from VSN. Patients with right hemisphere stroke and VSN were randomly assigned to two groups matched for clinical characteristics and given a 10-day treatment. On each day, all patients underwent visual scanning training and motor function training and received iTBS over the LDLPFC either at 80% resting motor threshold (RMT) or at 40% RMT before the trainings. MRI, the line bisection test, and the star cancelation test were performed before and after treatment. Patients who received iTBS at 80% RMT showed a largescale reduction in the resting-state functional connectivity extent, largely in the right attention network, and more significant improvement of behavioral performance compared with patients who received iTBS at 40% RMT. These results support that the LDLPFC potentially plays a key role in the modulation of attention networks in neglect. Increasing the activity of the LDPLPFC through iTBS can facilitate recovery from VSN in patients with stroke. NeuroReport 27:1261-1265 Copyright c 2016 Wolters Kluwer Health, Inc. All rights reserved.

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出版当年[2015]版:
大类 | 4 区 医学
小类 | 4 区 神经科学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 神经科学
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出版当年[2014]版:
Q4 NEUROSCIENCES
最新[2023]版:
Q4 NEUROSCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

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第一作者机构: [1]Department of Rehabilitation, Xuanwu Hospital Capital Medical University, Beijing, People’s Republic of China
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通讯机构: [*1]Department of Rehabilitation, Xuanwu Hospital Capital Medical University, Changchun Street, Xicheng District No. 45, Beijing 100053, People’s Republic of China
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