Intermittent theta burst stimulation modulates resting-state functional connectivity in the attention network and promotes behavioral recovery in patients with visual spatial neglect
Functional connectivity changes in the attention network are viewed as a physiological signature of visual spatial neglect (VSN). The left dorsal lateral prefrontal cortex (LDLPFC) is known to initiate and monitor top-down attentional control and dynamically adjust behavioral performance. This study aimed to investigate whether increasing the activity of the LDLPFC through intermittent. burst stimulation (iTBS) could modulate the resting-state functional connectivity in the attention network and facilitate recovery from VSN. Patients with right hemisphere stroke and VSN were randomly assigned to two groups matched for clinical characteristics and given a 10-day treatment. On each day, all patients underwent visual scanning training and motor function training and received iTBS over the LDLPFC either at 80% resting motor threshold (RMT) or at 40% RMT before the trainings. MRI, the line bisection test, and the star cancelation test were performed before and after treatment. Patients who received iTBS at 80% RMT showed a largescale reduction in the resting-state functional connectivity extent, largely in the right attention network, and more significant improvement of behavioral performance compared with patients who received iTBS at 40% RMT. These results support that the LDLPFC potentially plays a key role in the modulation of attention networks in neglect. Increasing the activity of the LDPLPFC through iTBS can facilitate recovery from VSN in patients with stroke. NeuroReport 27:1261-1265 Copyright c 2016 Wolters Kluwer Health, Inc. All rights reserved.
基金:
National Natural Science Found of China (81171024, 81671048).
第一作者机构:[1]Department of Rehabilitation, Xuanwu Hospital Capital Medical University, Beijing, People’s Republic of China
通讯作者:
通讯机构:[*1]Department of Rehabilitation, Xuanwu Hospital Capital Medical University, Changchun Street, Xicheng District No. 45, Beijing 100053, People’s Republic of China
推荐引用方式(GB/T 7714):
Lei Cao,Wei Fu,Yanming Zhang,et al.Intermittent theta burst stimulation modulates resting-state functional connectivity in the attention network and promotes behavioral recovery in patients with visual spatial neglect[J].NEUROREPORT.2016,27(17):1261-1265.doi:10.1097/WNR.0000000000000689.
APA:
Lei Cao,Wei Fu,Yanming Zhang,Su Huo,JuBao Du...&Weiqun Song.(2016).Intermittent theta burst stimulation modulates resting-state functional connectivity in the attention network and promotes behavioral recovery in patients with visual spatial neglect.NEUROREPORT,27,(17)
MLA:
Lei Cao,et al."Intermittent theta burst stimulation modulates resting-state functional connectivity in the attention network and promotes behavioral recovery in patients with visual spatial neglect".NEUROREPORT 27..17(2016):1261-1265