机构：[1]Department of Vascular Interventional Surgery, Siping Hospital of China Medical University,Siping, Jilin 136000[2]Tuhua Bioengineering Company Ltd.,Siping, Jilin 136000[3]Department of Orthopaedic Surgery, Siping Hospital of China Medical University, Siping, Jilin 136000[4]Department of Tissue Engineering, China Medical University, Shenyang, Liaoning 110122[5]Department of Vascular Interventional Surgery, Xuanwu Hospital of Capital Medical University, Beijing 100053首都医科大学宣武医院[6]The Key Tissue Engineering Laboratory of Jilin Province, Siping, Jilin 136000, P.R. China
This is a retrospective analysis of the clinical effects of transplant of mesenchymal stem cells (MSCs) derived from human umbilical cord-derived MSCs (hUC-MSCs) for the treatment of osteonecrosis of the femoral head (ONFH). The biological characteristics of hUC-MSCs were assessed using flow cytometry. Nine eligible patients were enrolled in the study as they adhered to the Association Research Circulation Osseous (ARCO) classification of stage II-IIIa, and hUC-MSCs were grafted by intra-arterial infusion. Organize effective perfusion was assessed using the oxygen delivery index (ODI). The results showed that the ODI was increased at three days post-operation. The MRI results revealed that at 12 and 24 months after treatment, the necrotic volume of the femoral heads was significantly reduced. No obvious abnormalities were observed. Taken together, these data indicate that intra-arterially infused hUC-MSCs migrate into the necrotic field of femoral heads and differentiate into osteoblasts, thus improving the necrosis of femoral heads. This finding suggested that intra-arterial infusion of hUC-MSCs MSCs is a feasible and relatively safe method for the treatment of femoral head necrosis.
基金：
the National High Technology Research and Development Program of (863 Program), nos. 2011AA020101 and 2012A020905.
第一作者机构：[1]Department of Vascular Interventional Surgery, Siping Hospital of China Medical University,Siping, Jilin 136000[2]Tuhua Bioengineering Company Ltd.,Siping, Jilin 136000
通讯作者：
通讯机构：[*1]The Key Tissue Engineering Laboratory of Jilin Province, 89 Nanyingbin Road, Siping, Jilin 136000, P.R. China[*2]Department of Vascular Interventional Surgery, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, P.R. China
推荐引用方式(GB/T 7714)：
CHUN CHEN,ZHIGUO QU,XIAOGUANG YIN,et al.Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: A three-year follow-up study[J].MOLECULAR MEDICINE REPORTS.2016,14(5):4209-4215.doi:10.3892/mmr.2016.5745.
APA：
CHUN CHEN,ZHIGUO QU,XIAOGUANG YIN,CHUNYU SHANG,QIANG AO...&YING LIU.(2016).Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: A three-year follow-up study.MOLECULAR MEDICINE REPORTS,14,(5)
MLA：
CHUN CHEN,et al."Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: A three-year follow-up study".MOLECULAR MEDICINE REPORTS 14..5(2016):4209-4215
