机构：[1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, 100053, China神经内科首都医科大学宣武医院[2]Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China[3]School of Mechanical, Electrical & Information Engineering, Shandong University, Weihai, Shandong Province, 264209, China[4]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China
Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer's disease (AD) occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) defects in SCD, diffusion images from 27 SCD (age=65.3+/-8.0), 35 aMCI (age=69.2+/-8.6) and 25 AD patients (age=68.3+/-9.4) and 37 normal controls (NC) (age=65.1+/-6.8) were compared using Tract-Based Spatial Statistics (TBSS). WM impairments common to the three patient groups were extracted, and fractional anisotropy (FA) values were averaged in each group. As compared to NC subjects, SCD patients displayed widespread WM alterations represented by decreased FA (p<0.05), increased mean diffusivity (MD; p<0.05), and increased radial diffusivity (RD; p<0.05). In addition, localized WM alterations showed increased axial diffusivity (AxD; p<0.05) similar to what was observed in aMCI and AD patients (p<0.05). In the shared WM impairment tracts, SCD patients had FA values between the NC group and the other two patient groups. In the NC and SCD groups, the AVLT-delayed recall score correlated with higher AxD (r=-0.333, p=0.045), MD (r=-0.351, p=0.03) and RD (r=-0.353, p=0.025). In both the aMCI and AD groups the diffusion parameters were highly correlated with cognitive scores. Our study suggests that SCD patients present with widespread WM changes, which may contribute to the early memory decline they experience.
基金：
the National Natural Science Foundation of China (Grant No. 31371007, 81430037, 30970823, 81501549),
Beijing Municipal Science & Technology Commission (Grant No. Z131100006813022),
Kallikrein Medical Research Program (Grant No. 201206006)
National Key Department of Neurology funded by Chinese Health and Family Planning Committee
第一作者机构：[1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, 100053, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, 100053, China[2]Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China[4]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China
推荐引用方式(GB/T 7714)：
Xuan-yu Li,Zhen-chao Tang,Yu Sun,et al.White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study[J].ONCOTARGET.2016,7(34):54405-54414.doi:10.18632/oncotarget.10091.
APA：
Xuan-yu Li,Zhen-chao Tang,Yu Sun,Jie Tian,Zhen-yu Liu&Ying Han.(2016).White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study.ONCOTARGET,7,(34)
MLA：
Xuan-yu Li,et al."White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study".ONCOTARGET 7..34(2016):54405-54414
医学