机构：[1]Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.[2]Cerebrovascular Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.首都医科大学宣武医院
Neurons can release damaged mitochondria and transfer them to astrocytes for disposal and recycling(1). This ability to exchange mitochondria may represent a potential mode of cell-to-cell signalling in the central nervous system. Here we show that astrocytes in mice can also release functional mitochondria that enter neurons. Astrocytic release of extracellular mitochondrial particles was mediated by a calcium-dependent mechanism involving CD38 and cyclic ADP ribose signalling. Transient focal cerebral ischaemia in mice induced entry of astrocytic mitochondria into adjacent neurons, and this entry amplified cell survival signals. Suppression of CD38 signalling by short interfering RNA reduced extracellular mitochondria transfer and worsened neurological outcomes. These findings suggest a new mitochondrial mechanism of neuroglial crosstalk that may contribute to endogenous neuroprotective and neurorecovery mechanisms after stroke.
基金：
the National Institutes of Health (NIH),
the Rappaport Foundation,
the China National Natural Science Foundation Award For Distinguished Young Scholars.
第一作者机构：[1]Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.
通讯作者：
通讯机构：[1]Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.[2]Cerebrovascular Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Kazuhide Hayakawa,Elga Esposito,Xiaohua Wang,et al.Transfer of mitochondria from astrocytes to neurons after stroke[J].NATURE.2016,535(7613):551-+.doi:10.1038/nature18928.
APA：
Kazuhide Hayakawa,Elga Esposito,Xiaohua Wang,Yasukazu Terasaki,Yi Liu...&Eng H. Lo.(2016).Transfer of mitochondria from astrocytes to neurons after stroke.NATURE,535,(7613)
MLA：
Kazuhide Hayakawa,et al."Transfer of mitochondria from astrocytes to neurons after stroke".NATURE 535..7613(2016):551-+
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