机构：[1]State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, P. R. China.[2]Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing 100875, P. R. China.[3]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China.放射科首都医科大学宣武医院[4]Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam 1007 MB, The Netherlands.[5]Department of Anatomy and Neuroscience, VU University Medical Center, Amsterdam 1007 MB, The Netherlands.[6]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China.神经内科首都医科大学宣武医院[7]Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, P. R. China.
The brain connectome of multiple sclerosis (MS) has been investigated by several previous studies; however, it is still unknown how the network changes in clinically isolated syndrome (CIS), the earliest stage of MS, and how network alterations on a functional level relate to the structural level in MS disease. Here, we investigated the topological alterations of both the structural and functional connectomes in 41 CIS and 32 MS patients, compared to 35 healthy controls, by combining diffusion tensor imaging and resting-state functional MRI with graph analysis approaches. We found that the structural connectome showed a deviation from the optimal pattern as early as the CIS stage, while the functional connectome only showed local changes in MS patients, not in CIS. When comparing two patient groups, the changes appear more severe in MS. Importantly, the disruptions of structural and functional connectomes in patients occurred in the same direction and locally correlated in sensorimotor component. Finally, the extent of structural network changes was correlated with several clinical variables in MS patients. Together, the results suggested early disruption of the structural brain connectome in CIS patients and provided a new perspective for investigating the relationship of the structural and functional alterations in MS.
基金：
the ECTRIMS-MAGNMIS Fellowship from ECTRIMS
the 973 program (Grant No. 2013CB837300),
the National Natural Science Foundation of China (Grant Nos 81471732; 81501736 and 30930029),
the Beijing Natural Science fund (Grant No. 7162077),
the Beijing Nova Program (Grant No. xx2013045),
the Beijing New Medical Discipline Based Group (Grant No. 100270569)
the Fundamental Research Funds for the Central Universities (Grant No. 2013YB28).
第一作者机构：[1]State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, P. R. China.[2]Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing 100875, P. R. China.
通讯作者：
通讯机构：[3]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China.[4]Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam 1007 MB, The Netherlands.[7]Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, P. R. China.
推荐引用方式(GB/T 7714)：
Ni Shu,Yunyun Duan,Mingrui Xia,et al.Disrupted topological organization of structural and functional brain connectomes in clinically isolated syndrome and multiple sclerosis[J].SCIENTIFIC REPORTS.2016,6:doi:10.1038/srep29383.
APA：
Ni Shu,Yunyun Duan,Mingrui Xia,Menno M. Schoonheim,Jing Huang...&Yaou Liu.(2016).Disrupted topological organization of structural and functional brain connectomes in clinically isolated syndrome and multiple sclerosis.SCIENTIFIC REPORTS,6,
MLA：
Ni Shu,et al."Disrupted topological organization of structural and functional brain connectomes in clinically isolated syndrome and multiple sclerosis".SCIENTIFIC REPORTS 6.(2016)
