机构：[a]Northeastern University, School of Information Science and Engineering, No. 11 Lane Three Culture Road, Heping Area, Shenyang 110819, China[b]Capital Medical University, Department of Neurology, Xuan Wu Hospital, No. 45 Changchun Street, Xicheng District, Beijing 100053, China神经内科首都医科大学宣武医院
A blockage of the middle cerebral artery (MCA) on the cortical branch will seriously affect the blood supply of the cerebral cortex. Real-time monitoring of MCA hemodynamic parameters is critical for therapy and rehabilitation. Optical coherence tomography (OCT) is a powerful imaging modality that can produce not only structural images but also functional information on the tissue. We use OCT to detect hemodynamic changes after MCA branch occlusion. We injected a selected dose of endothelin-1 (ET-1) at a depth of 1 mm near the MCA and let the blood vessels follow a process first of occlusion and then of slow reperfusion as realistically as possible to simulate local cerebral ischemia. During this period, we used optical microangiography and Doppler OCT to obtain multiple hemodynamic MCA parameters. The change trend of these parameters from before to after ET-1 injection clearly reflects the dynamic regularity of the MCA. These results show the mechanism of the cerebral ischemia-reperfusion process after a transient middle cerebral artery occlusion and confirm that OCT can be used to monitor hemodynamic parameters. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
基金：
National Natural Science Foundation of China (31170956, 61501100, 81301208, and 61275214),
Hebei Provincial Natural Science Foundation of China (A2015501002 and H2015501133).
Fundamental Research Funds for the Central Universities (N120223001),
Research Fund for Higher School Science and Technology in Hebei Province (QN20132014),
Science and Technology Research and Development project funds of Shenzhen(JCYJ20120618142137681),
the Colleges and Universities Scientific Research projects in Hebei Province (Z2015207).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|3 区医学
小类|2 区光学3 区生化研究方法3 区核医学
最新[2025]版：
大类|3 区医学
小类|2 区生化研究方法3 区光学3 区核医学
JCR分区：
出版当年[2014]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ1OPTICSQ2BIOCHEMICAL RESEARCH METHODS
最新[2023]版：
Q2BIOCHEMICAL RESEARCH METHODSQ2OPTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[a]Northeastern University, School of Information Science and Engineering, No. 11 Lane Three Culture Road, Heping Area, Shenyang 110819, China
通讯作者：
通讯机构：[a]Northeastern University, School of Information Science and Engineering, No. 11 Lane Three Culture Road, Heping Area, Shenyang 110819, China
推荐引用方式(GB/T 7714)：
Jian Liu ,Yushu Ma ,Shidan Dou ,et al.Hemodynamic changes in a rat parietal cortex after endothelin-1-induced middle cerebral artery occlusion monitored by optical coherence tomography[J].JOURNAL OF BIOMEDICAL OPTICS.2016,21(7):75014.doi:10.1117/1.JBO.21.7.075014.
APA：
Jian Liu,,Yushu Ma,,Shidan Dou,,Yi Wang,,Dongsheng La,...&Zhenhe Ma.(2016).Hemodynamic changes in a rat parietal cortex after endothelin-1-induced middle cerebral artery occlusion monitored by optical coherence tomography.JOURNAL OF BIOMEDICAL OPTICS,21,(7)
MLA：
Jian Liu,,et al."Hemodynamic changes in a rat parietal cortex after endothelin-1-induced middle cerebral artery occlusion monitored by optical coherence tomography".JOURNAL OF BIOMEDICAL OPTICS 21..7(2016):75014
