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Task and Resting-State fMRI Reveal Altered Salience Responses to Positive Stimuli in Patients with Major Depressive Disorder

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机构： [1]Beijing Advanced Innovation Center for Future Internet Technology, Beijing University of Technology, Beijing, China, [2]Department of Life Science and Informatics, Maebashi Institute of Technology, Maebashi, Gunma, Japan, [3]Department of Systems Life Engineering, Maebashi Institute of Technology, Maebashi, Gunma, Japan, [4]International WIC Institute, Beijing University of Technology, Beijing, China, [5]Beijing International Collaboration Base on Brain Informatics and Wisdom Services, Beijing, China, [6]Beijing Key Laboratory of MRI and Brain Informatics, Beijing, China, [7]Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China, [8]Ubiquitous Awareness and Intelligent Solutions Lab, Lanzhou University, Lanzhou, Gansu, China, [9]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China

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Altered brain function in patients with major depressive disorder (MDD) has been repeatedly demonstrated by task-based and resting-state studies, respectively. However, less is known concerning whether overlapped abnormalities in functional activities across modalities exist in MDD patients. To find out the answer, we implemented an fMRI experiment and collected both task and resting-state data from 19 MDD patients and 19 matched, healthy, controls. A distraction paradigm involving emotionally valenced pictures was applied to induce affective responses in subjects. As a result, concurrent deficits were found in arousing activation during a positive task in both the reward circuit and salience network (SN) that is composed of the dorsal part of anterior cingulate cortex (dACC) and bilateral anterior insulae (AI) in only the MDD group. Subsequent amplitude of low frequency fluctuations (ALFF) and functional connectivity analyses based on resting-state data exhibited consistent alterations in the bilateral AI of MDD patients, and indicated patients' difficulties in regulating the balance between central executive network (CEN) and default mode network (DMN) due to altered connectivity among the CEN, DMN, and SN. Our findings provide new evidence demonstrating impaired salience processing and resulting alterations in responses to positive stimuli in MDD patients. Furthermore, brain abnormalities synchronized across functional states in MDD patients can be evidenced by a combination of task and resting-state fMRI analyses.

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出版当年[2015]版：

大类 | 3 区生物

小类 | 3 区综合性期刊

最新[2023]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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出版当年[2014]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 2.9 最新[2023版] 3.3 最新五年平均 3.234 出版当年[2014版] 3.702 出版当年五年平均 3.534 出版前一年[2013版] 3.057 出版后一年[2015版]

第一作者：

第一作者机构： [1]Beijing Advanced Innovation Center for Future Internet Technology, Beijing University of Technology, Beijing, China, [2]Department of Life Science and Informatics, Maebashi Institute of Technology, Maebashi, Gunma, Japan, [5]Beijing International Collaboration Base on Brain Informatics and Wisdom Services, Beijing, China, [6]Beijing Key Laboratory of MRI and Brain Informatics, Beijing, China,

通讯作者：

通讯机构： [1]Beijing Advanced Innovation Center for Future Internet Technology, Beijing University of Technology, Beijing, China, [2]Department of Life Science and Informatics, Maebashi Institute of Technology, Maebashi, Gunma, Japan, [4]International WIC Institute, Beijing University of Technology, Beijing, China, [5]Beijing International Collaboration Base on Brain Informatics and Wisdom Services, Beijing, China, [6]Beijing Key Laboratory of MRI and Brain Informatics, Beijing, China,

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