机构：[1]Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China[2]Genos Glycoscience, Zagreb, Croatia[3]MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK[4]School of Medical Sciences, Edith Cowan University, Perth, WA, Australia[5]Center for Physical Examination, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[6]Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK[7]Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia[8]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University[9]International Medical Centre, Chinese PLA General Hospital, Beijing, China[10]Institute of Cytology and Genetics SB RAS[11]Novosibirsk State University, Novosibirsk, Russia
More than half of all known proteins, and almost all membrane and extra-cellular proteins have oligosaccharide structures or glycans attached to them. Defects in glycosylation pathways are directly involved in at least 30 severe human diseases. A multiple center cross-sectional study (China, Croatia, and Scotland) was carried out to investigate the possible association between hypertension and IgG glycosylation. A hydrophilic interaction chromatography of fluorescently labeled glycans was used to analyze N-glycans attached to IgG in plasma samples from a total of 4757 individuals of Chinese Han, Croatian, and Scottish ethnicity. Five glycans (IgG with digalactosylated glycans) significantly differed in participants with prehypertension or hypertension compared to those with normal blood pressure, while additional 17 glycan traits were only significantly differed in participants with hypertension compared to those of normal blood pressure. These glycans were also significant correlated with systolic blood pressure (SBP) or diastolic blood pressure (DBP). The present study demonstrated for the 1st time an association between hypertension and IgG glycome composition. These findings suggest that the individual variation in N-glycosylation of IgG contributes to pathogenesis of hypertension, presumably via its effect on proand/or anti-inflammatory pathways.
基金：
the National Natural Science Foundation of China (81370083, 81273170, 81573215, 81373099),
the National "12th Five-Year" Plan for Science and Technology Support, China (2012BAI37B03),
the Joint Project of the Australian National Health and Medical Research Council and the National Natural Science Foundation of China (NHMRC-APP1112767-NSFC 81561128020),
Connecting Australian-European Science and Innovation Excellence (CAESIE- Priming Grant 1747853),
Australian National Health and Medical Research Council (NHMRC-APP1046711),
ECU Industry Collaboration Scheme 2013 (G1001368)
EU-fp-7 Pain-Omics (602736) for the support.
the Importation and Development of High-Calibre Talents Project of Beijing Municipal Institutions (CIT&TCD201404185);
Beijing Higher Education Young Elite Teacher Project (YETP1671)
Beijing Nova Program (Z141107001814058);
Russian Science Foundation (14-14-00313),
The Medical Research Council UK and the Croatian Science Foundation (8875).
第一作者机构：[1]Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China[4]School of Medical Sciences, Edith Cowan University, Perth, WA, Australia
通讯作者：
通讯机构：[*1]School of Medical Sciences, Edith Cowan University, Perth WA 6027, Australia[*2]Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb 10000, Croatia[*3]International Medical Centre, Chinese PLA General Hospital, Beijing 100853, China
推荐引用方式(GB/T 7714)：
Youxin Wang,Lucija Klaric,Xinwei Yu,et al.The Association Between Glycosylation of Immunoglobulin G and Hypertension A Multiple Ethnic Cross-Sectional Study[J].MEDICINE.2016,95(17):e3379.doi:10.1097/MD.0000000000003379.
APA：
Youxin Wang,Lucija Klaric,Xinwei Yu,Kujtim Thaqi,Jing Dong...&Wei Wang.(2016).The Association Between Glycosylation of Immunoglobulin G and Hypertension A Multiple Ethnic Cross-Sectional Study.MEDICINE,95,(17)
MLA：
Youxin Wang,et al."The Association Between Glycosylation of Immunoglobulin G and Hypertension A Multiple Ethnic Cross-Sectional Study".MEDICINE 95..17(2016):e3379
