机构：[a]Departments of Neurology,Beijing Tiantan Hospital, Capital Medical University, Beijing, China[b]Departments of Geriatrics,Beijing Tiantan Hospital, Capital Medical University, Beijing, China[c]Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[d]Department of Physiology, Capital Medical University, Beijing, China[e]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China[f]Department of Neurobiology, Beijing Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[g]Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China[h]China National Clinical Research Center for Neurological Diseases, Beijing, China[i]Beijing Key Laboratory on Parkinson’s Disease, Beijing, China
Background and Purpose The aim of this study was to identify the clinical characteristics and potential mechanisms relevant to pathological proteins in Parkinson's disease (PD) patients who experience fatigue. Methods PD patients (n=102) were evaluated using a fatigue severity scale and scales for motor and nonmotor symptoms. The levels of three pathological proteins-alpha-synuclein oligomer, beta-amyloid (A beta)(1-42), and tau-were measured in 102 cerebrospinal fluid (CSF) samples from these PD patients. Linear regression analyses were performed between fatigue score and the CSF levels of the above-listed pathological proteins in PD patients. Results The frequency of fatigue in the PD patients was 62.75%. The fatigue group had worse motor symptoms and anxiety, depression, and autonomic dysfunction. The CSF level of alpha-synuclein oligomer was higher and that of A beta(1-42) was lower in the fatigue group than in the non-fatigue group. In multiple linear regression analyses, fatigue severity was significantly and positively correlated with the a-synuclein oligomer level in the CSF of PD patients, after adjusting for confounders. Conclusions PD patients experience a high frequency of fatigue. PD patients with fatigue have worse motor and part nonmotor symptoms. Fatigue in PD patients is associated with an increased alpha-synuclein oligomer level in the CSF.
基金：
the National Key Basic Research Program of China (2011CB504100),
the National Natural Science Foundation of China (81571229, 81071015, 30770745),
the Natural Science Foundation of Beijing, China (7082032),
the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2013BAI09B03),
the project of Beijing Institute for Brain Disorders(BIBD PXM2013_014226_07_000084),
the High Level Technical Personnel Training Project of Beijing Health System, China (2009-3-26),
the Project of Construction of Innovative Teams and Teacher Career Development
for Universities and Colleges Under Beijing Municipality(IDHT20140514),
the Capital Clinical Characteristic Application Research(Z121107001012161),
the Beijing Healthcare Research Project(JING-15-2, JING-15-3),
the Excellent Personnel Training Project of Beijing, China (20071D0300400076),
the Important National Science &Technology Specific Projects (2011ZX09102-003-01),
the Key Project of National Natural Science Foundation of China (81030062),
the Key Project of Beijing Natural Science Foundation (kz200910025001)
the Basic-Clinical Research Cooperation Funding of Capital Medical University(10JL49, 14JL15, 2015-JL-PT-X04),
Youth Research Fund, Beijing Tiantan Hospital, Capital Medical University, China (2014-YQN-YS-18).
第一作者机构：[a]Departments of Neurology,Beijing Tiantan Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*1]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Li-Jun Zuo,Shu-Yang Yu,Fang Wang,et al.Parkinson's Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to alpha-Synuclein Oligomer[J].JOURNAL OF CLINICAL NEUROLOGY.2016,12(2):172-180.doi:10.3988/jcn.2016.12.2.172.
APA：
Li-Jun Zuo,Shu-Yang Yu,Fang Wang,Yang Hu,Ying-Shan Piao...&Wei Zhang.(2016).Parkinson's Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to alpha-Synuclein Oligomer.JOURNAL OF CLINICAL NEUROLOGY,12,(2)
MLA：
Li-Jun Zuo,et al."Parkinson's Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to alpha-Synuclein Oligomer".JOURNAL OF CLINICAL NEUROLOGY 12..2(2016):172-180
