机构：[1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China放射科首都医科大学宣武医院[2]Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam,VU University Medical Center, Amsterdam, the Netherlands[3]Department of Anatomy and Neurosciences, Section of Clinical Neuroscience,VU University Medical Center, Amsterdam, the Netherlands[4]Department of Physics and Medical Technology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands[5]Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University, General Hospital, Tianjin, P.R. China[6]Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St. Josef Hospital, Ruhr University, Bochum, Germany[7]Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany
BACKGROUND AND PURPOSE: Spinal cord atrophy is a common and clinically relevant characteristic in multiple sclerosis. We aimed to perform a multicenter validation study of mean upper cervical cord area measurements in patients with multiple sclerosis and healthy controls from head MR images and to explore the effect of gadolinium administration on mean upper cervical cord area measurements. MATERIALS AND METHODS: We recruited 97 subjects from 3 centers, including 60 patients with multiple sclerosis of different disease types and 37 healthy controls. Both cervical cord and head 3D T1-weighted images were acquired. In 11 additional patients from 1 center, head images before and after gadolinium administration and cervical cord images after gadolinium administration were acquired. The mean upper cervical cord area was compared between cervical cord and head images by using intraclass correlation coefficients (ICC) for both consistency (ICCconsist) and absolute (ICCabs) agreement. RESULTS: There was excellent agreement of mean upper cervical cord area measurements from head and cervical cord images in the entire group (ICCabs = 0.987) and across centers and disease subtypes. The mean absolute difference between the mean upper cervical cord area measured from head and cervical cord images was 2 mm(2) (2.3%). Additionally, excellent agreement was found between the mean upper cervical cord area measured from head images with and without gadolinium administration (ICCabs = 0.991) and between the cervical cord and head images with gadolinium administration (ICCabs = 0.992). CONCLUSIONS: Excellent agreement between mean upper cervical cord area measurements on head and cervical cord images was observed in this multicenter study, implying that upper cervical cord atrophy can be reliably measured from head images. Postgadolinium head or cervical cord images may also be suitable for measuring mean upper cervical cord area.
基金：
the European Committee for Treatment and Research in Multiple Sclerosis/Magnetic Research Imaging in Multiple Sclerosis Fellowship from the European Committee for Treatment and Research in Multiple Sclerosis
the National Science Foundation of China (No. 81101038 and 81501736),
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (No. ZYLX201609),
the Beijing Natural Science fund (No. 7133244),
the Beijing Nova Programme (No. xx2013045),
the Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-Year Plan Period (No.2012BAI10B04).
the German Federal Ministry for Education and Research, Bundesministerium fu¨r Bildung und Forschung,
the German Competence Network Multiple Sclerosis (Kompetenznetz Multiple Sklerose) (No. 01GI0914).
the program grant by the Dutch MS Research Foundation (Nos. 09-358d and 14-358e).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|3 区医学
小类|2 区核医学3 区临床神经病学3 区神经成像
最新[2023]版：
大类|3 区医学
小类|3 区临床神经病学3 区神经成像3 区核医学
JCR分区：
出版当年[2014]版：
Q1CLINICAL NEUROLOGYQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2NEUROIMAGING
最新[2023]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2CLINICAL NEUROLOGYQ2NEUROIMAGING
第一作者机构：[1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China[2]Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam,VU University Medical Center, Amsterdam, the Netherlands[5]Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University, General Hospital, Tianjin, P.R. China[*1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[*1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Y. Liu ,C. Lukas ,M.D. Steenwijk ,et al.Multicenter Validation of Mean Upper Cervical Cord Area Measurements from Head 3D T1-Weighted MR Imaging in Patients with Multiple Sclerosis[J].AMERICAN JOURNAL OF NEURORADIOLOGY.2016,37(4):749-754.doi:10.3174/ajnr.A4635.
APA：
Y. Liu,,C. Lukas,,M.D. Steenwijk,,M. Daams,,A. Versteeg,...&H. Vrenken.(2016).Multicenter Validation of Mean Upper Cervical Cord Area Measurements from Head 3D T1-Weighted MR Imaging in Patients with Multiple Sclerosis.AMERICAN JOURNAL OF NEURORADIOLOGY,37,(4)
MLA：
Y. Liu,,et al."Multicenter Validation of Mean Upper Cervical Cord Area Measurements from Head 3D T1-Weighted MR Imaging in Patients with Multiple Sclerosis".AMERICAN JOURNAL OF NEURORADIOLOGY 37..4(2016):749-754
