机构：[1]Shenzhen Key Lab for MRI, BCMIIS, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China.[2]Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.[3]Siemens Healthcare, Los Angeles, California, USA.[4]Xuanwu Hospital, Capital Medical University, Beijing, China.首都医科大学宣武医院放射科[5]Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, California, USA
PurposeThree-dimensional (3D) dark-blood MRI has shown great potential in coronary artery plaque evaluation. However, substantial variability in quantification could result from superficial calcification because of its low signal. To address this issue, a 3D coronary dark-blood interleaved with gray-blood (cDIG) technique was developed. MethodscDIG is based on a balanced steady-state free precession readout combined with a local re-inversion-based double-inversion-recovery (LocReInv-DIR) preparation. The LocReInv-DIR is applied every two RR intervals. Dark-blood and gray-blood contrasts are collected in the first and second RR interval, respectively. To improve the respiratory gating efficiency, two independent navigators were developed to separately gate the respiratory motion for the two interleaved acquisitions. In vivo experiments in eight healthy subjects and one patient were conducted to validate the technique. ResultscDIG provided dual-contrasts without compromise in scan time. The dark-blood images with cDIG demonstrated excellent wall and lumen signal performances and morphological measurements. Advantageously, cDIG yielded a second contrast that was shown to help identify the superficial calcification in the coronary plaque of a patient. ConclusionA novel technique was developed for obtaining 3D coronary vessel wall and gray lumen images. The additional contrast may aid in identifying calcified nodules and thus potentially improve the evaluation of coronary plaque burden. Magn Reson Med 75:997-1007, 2016. (c) 2015 Wiley Periodicals, Inc.
基金：
Grant sponsor: NIH/NIBIB; Grant number: R01 EB002623;
Grant sponsor:National Basic Research Program of China;
Grant number: 2010CB732600;
Grant sponsor: National Science Foundation of China International Cooperation and Exchange;
Grant numbers: No.81120108012, No.81328013, No.81229001;
Grant sponsor: Science Foundation of Shenzhen;
Grant number: No. JCYJ20140417113430603.
第一作者机构：[1]Shenzhen Key Lab for MRI, BCMIIS, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China.[2]Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
通讯作者：
通讯机构：[*1]Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
推荐引用方式(GB/T 7714)：
Guoxi Xie ,Xiaoming Bi ,Jiabin Liu ,et al.Three-dimensional coronary dark-blood interleaved with gray-blood (cDIG) magnetic resonance imaging at 3 tesla[J].MAGNETIC RESONANCE IN MEDICINE.2016,75(3):997-1007.doi:10.1002/mrm.25585.
APA：
Guoxi Xie,,Xiaoming Bi,,Jiabin Liu,,Qi Yang,,Yutaka Natsuaki,...&Zhaoyang Fan.(2016).Three-dimensional coronary dark-blood interleaved with gray-blood (cDIG) magnetic resonance imaging at 3 tesla.MAGNETIC RESONANCE IN MEDICINE,75,(3)
MLA：
Guoxi Xie,,et al."Three-dimensional coronary dark-blood interleaved with gray-blood (cDIG) magnetic resonance imaging at 3 tesla".MAGNETIC RESONANCE IN MEDICINE 75..3(2016):997-1007
