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Characteristics of lesional and extra-lesional cortical grey matter in relapsing-remitting and secondary progressive multiple sclerosis: A magnetisation transfer and diffusion tensor imaging study

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收录情况： ◇ SCIE

作者：
ozgür Yaldizli,[1,2,*1,*2] * ; Matteo Pardini,[1,3] ; Varun Sethi,[1] ; Nils Muhlert,[1,4] ; Zheng Liu,[1,5] ; Daniel J Tozer,[1] ; Rebecca S Samson,[1] ; Claudia AM Wheeler-Kingshott,[1] ; Tarek A Yousry,[1,6,7,8] ; David H Miller[1,6] ; Declan T Chard[1,6] ;
机构： [1]Queen Square MS Centre, UCL Institute of Neurology, UK [2]MS Center, University Hospital Basel, Switzerland [3]Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy [4]School of Psychology and Cardiff University Brain Research Imaging Centre, Cardiff University, UK [5]Department of Neurology, Xuanwu Hospital of Capital Medical University, China [6]National Institute for Health Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre, UK [7]Brain Repair and Rehabilitation, UCL Institute of Neurology, UK [8]Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UK
出处：
DOI： 10.1177/1352458515586085
ISSN：

关键词： MRI Multiple sclerosis grey matter lesions normal-appearing grey matter magnetisation transfer imaging diffusion tensor imaging

摘要：
Background: In multiple sclerosis (MS), diffusion tensor and magnetisation transfer imaging are both abnormal in lesional and extra-lesional cortical grey matter, but differences between clinical subtypes and associations with clinical outcomes have only been partly assessed. Objective: To compare mean diffusivity, fractional anisotropy and magnetisation transfer ratio (MTR) in cortical grey matter lesions (detected using phase-sensitive inversion recovery (PSIR) imaging) and extra-lesional cortical grey matter, and assess associations with disability in relapse-onset MS. Methods: Seventy-two people with MS (46 relapsing-remitting (RR), 26 secondary progressive (SP)) and 36 healthy controls were included in this study. MTR, mean diffusivity and fractional anisotropy were measured in lesional and extra-lesional cortical grey matter. Results: Mean fractional anisotropy was higher and MTR lower in lesional compared with extra-lesional cortical grey matter. In extra-lesional cortical grey matter mean fractional anisotropy and MTR were lower, and mean diffusivity was higher in the MS group compared with controls. Mean MTR was lower and mean diffusivity was higher in lesional and extra-lesional cortical grey matter in SPMS when compared with RRMS. These differences were independent of disease duration. In multivariate analyses, MTR in extra-lesional more so than lesional cortical grey matter was associated with disability. Conclusion: Magnetic resonance abnormalities in lesional and extra-lesional cortical grey matter are greater in SPMS than RRMS. Changes in extra-lesional compared with lesional cortical grey matter are more consistently associated with disability.

基金：
MAGNIMS/ECTRIMS and the University of Basel, Switzerland. The NMR Research Unit is supported by the MS Society of Great Britain and Northern Ireland the UCL UCLH Comprehensive Biomedical Research Centre. The MS Society of Great Britain and Northern Ireland has provided financial support for staff and research costs (grant no. 917-09).
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 神经科学
JCR分区：
出版当年[2014]版：
Q1 CLINICAL NEUROLOGY
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者机构： [1]Queen Square MS Centre, UCL Institute of Neurology, UK [2]MS Center, University Hospital Basel, Switzerland [*1]Queen Square MS Centre, NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK [*2]MS Center, Department of Neurology, University Hospital Basel, Basel, Switzerland.
通讯作者：
通讯机构： [*1]Queen Square MS Centre, NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK [*2]MS Center, Department of Neurology, University Hospital Basel, Basel, Switzerland.
推荐引用方式(GB/T 7714)：
ozgür Yaldizli ,Matteo Pardini ,Varun Sethi ,et al.Characteristics of lesional and extra-lesional cortical grey matter in relapsing-remitting and secondary progressive multiple sclerosis: A magnetisation transfer and diffusion tensor imaging study[J].MULTIPLE SCLEROSIS JOURNAL.2016,22(2):150-159.doi:10.1177/1352458515586085.
APA：
ozgür Yaldizli,,Matteo Pardini,,Varun Sethi,,Nils Muhlert,,Zheng Liu,...&Declan T Chard.(2016).Characteristics of lesional and extra-lesional cortical grey matter in relapsing-remitting and secondary progressive multiple sclerosis: A magnetisation transfer and diffusion tensor imaging study.MULTIPLE SCLEROSIS JOURNAL,22,(2)
MLA：
ozgür Yaldizli,,et al."Characteristics of lesional and extra-lesional cortical grey matter in relapsing-remitting and secondary progressive multiple sclerosis: A magnetisation transfer and diffusion tensor imaging study".MULTIPLE SCLEROSIS JOURNAL 22..2(2016):150-159

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