机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China神经外科首都医科大学宣武医院[2]Departments of Psychology and Linguistics, Xidian University, Xi’an 710126, China[3]Neuroimaging Laboratory, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China[4]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China放射科首都医科大学宣武医院[5]Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[6]Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China[7]Center of Stroke, Beijing Institute for Brain Disorder, Beijing 100069, China[8]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China[9]Center of Epilepsy, Beijing Institute for Brain Disorder, Beijing 100069, China
Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective functional connectivity changes within the semantic cognition network between these two groups and those from normal controls. We found that graymatter atrophy of leftmTLE patients was more severe than that of right mTLE patients in the whole brain and especially within the semantic cognition network in their contralateral hemisphere. It suggested that seizure attacks were rather targeted than random for patients with hippocampal sclerosis (HS) in the dominant hemisphere. Functional connectivity analysis during resting state fMRI revealed that subregions of the anterior temporal lobe (ATL) in the leftHS patients were no longer effectively connected. Further, we found that, unlike in right HS patients, increased causal linking between ipsilateral regions in the leftHS epilepsy patients cannot make up for their decreased contralateral interaction. It suggested that weakened contralateral connection and disrupted effective interaction between subregions of the unitary, transmodal hub of the ATL may be the primary cause of anomia in the left HS patients.
基金：
the National Natural Science Foundation of China (81522021,31400962,81371201,and 31371026),
the BeijingMunicipal Science&Technology Commission (Z141100002114034),
the China Postdoctoral Science Foundation (2015M582400).
第一作者机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China[9]Center of Epilepsy, Beijing Institute for Brain Disorder, Beijing 100069, China
推荐引用方式(GB/T 7714)：
Xiaotong Fan ,Hao Yan ,Yi Shan ,et al.Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients[J].NEURAL PLASTICITY.2016,2016:doi:10.1155/2016/8583420.
APA：
Xiaotong Fan,,Hao Yan,,Yi Shan,,Kun Shang,,XiaocuiWang,...&Guoguang Zhao.(2016).Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients.NEURAL PLASTICITY,2016,
MLA：
Xiaotong Fan,,et al."Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients".NEURAL PLASTICITY 2016.(2016)
