机构：[1]College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China[2]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China放射科首都医科大学宣武医院[3]Beijing Key Lab of MRI and Brain Informatics, Beijing 100053, China磁共振成像脑信息学北京市重点实验室首都医科大学宣武医院
Purpose. The present study aimed to explore the changes of amplitude of low-frequency fluctuations (ALFF) at rest in patients with Parkinson's disease (PD). Methods. Twenty-four PD patients and 22 healthy age-matched controls participated in the study. ALFF was measured on the whole brain of all participants. A two-sample t-test was then performed to detect the group differences with age, gender, education level, head motion, and gray matter volume as covariates. Results. It was showed that PD patients had significantly decreased ALFF in the left thalamus/caudate and right insula/inferior prefrontal gyrus, whereas they had increased ALFF in the right medial prefrontal cortex (BA 8/6) and dorsolateral prefrontal cortex (BA 9/10). Conclusions. Our results indicated that significant alterations of ALFF in the subcortical regions and prefrontal cortex have been detected in PD patients, independent of age, gender, education, head motion, and structural atrophy. The current findings further provide insights into the biological mechanism of the disease.
基金：
the National Natural Science Foundation of China (61473196, 61373101,and 31400958),
BeijingNova Program(nos. Z12111000250000 and Z131107000413120),
the Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(CNLZD1302),
Key Projects in the National Science and Technology Pillar Programduring the Twelfth Five-Year Plan Period (no. 2012BAI10B04),
Science and Technology Industrial Project of Shanxi Province (20140321002-01).
第一作者机构：[1]College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China
通讯作者：
通讯机构：[2]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China[3]Beijing Key Lab of MRI and Brain Informatics, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Jie Xiang ,Xiuqin Jia ,Huizhuo Li ,et al.Altered Spontaneous Brain Activity in Cortical and Subcortical Regions in Parkinson's Disease[J].PARKINSONS DISEASE.2016,2016:doi:10.1155/2016/5246021.
APA：
Jie Xiang,,Xiuqin Jia,,Huizhuo Li,,Jiawei Qin,,Peipeng Liang,&Kuncheng Li.(2016).Altered Spontaneous Brain Activity in Cortical and Subcortical Regions in Parkinson's Disease.PARKINSONS DISEASE,2016,
MLA：
Jie Xiang,,et al."Altered Spontaneous Brain Activity in Cortical and Subcortical Regions in Parkinson's Disease".PARKINSONS DISEASE 2016.(2016)
