机构：[1]Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA,[2]Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China,[3]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China中美神经科学研究所首都医科大学宣武医院
Mild physical hypothermia after stroke has been associated with positive outcomes. Despite the well-studied beneficial effects of hypothermia in the treatment of stroke, lack of precise temperature control, intolerance for the patient, and immunosuppression are some of the reasons which limit its clinical translation. Pharmacologically induced hypothermia has been explored as a possible treatment option following stroke in animal models. Currently, there are eight classes of pharmacological agents/agonists with hypothermic effects affecting a multitude of systems including cannabinoid, opioid, transient receptor potential vanilloid 1 (TRPV1), neurotensin, thyroxine derivatives, dopamine, gas, and adenosine derivatives. Interestingly, drugs in the TRPV1, neurotensin, and thyroxine families have been shown to have effects in thermoregulatory control in decreasing the compensatory hypothermic response during cooling. This review will briefly present drugs in the eight classes by summarizing their proposed mechanisms of action as well as side effects. Reported thermoregulatory effects of the drugs will also be presented. This review offers the opinion that these agents may be useful in combination therapies with physical hypothermia to achieve faster and more stable temperature control in hypothermia.
基金：
American Heart Association Grant-in-Aid (grant number 14GRNT20460246),
Merit Review Award (grant number I01RX-001964-01)
the US Department of Veterans Affairs Rehabilitation R&D Service,
National Natural Science Foundation of China (grant number 81501141);
Talent Training Program of Beijing Ministry of Organization (grant number 2013D008011000002).
第一作者机构：[1]Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA,
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Beijing Luhe Hospital, Capital Medical University, No. 82 Xinhua South Road, Tongzhou District, Beijing, China, 101149.
推荐引用方式(GB/T 7714)：
Kaiyin Liu,Hajra Khan,Xiaokun Geng,et al.Pharmacological hypothermia: a potential for future stroke therapy?[J].NEUROLOGICAL RESEARCH.2016,38(6):478-490.doi:10.1080/01616412.2016.1187826.
APA：
Kaiyin Liu,Hajra Khan,Xiaokun Geng,Jun Zhang&Yuchuan Ding.(2016).Pharmacological hypothermia: a potential for future stroke therapy?.NEUROLOGICAL RESEARCH,38,(6)
MLA：
Kaiyin Liu,et al."Pharmacological hypothermia: a potential for future stroke therapy?".NEUROLOGICAL RESEARCH 38..6(2016):478-490
