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Drebrin and cognitive impairment

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收录情况： ◇ SCIE

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机构： [a]Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China [b]Department of Central Laboratory, XuanWu Hospital, Capital Medical University, Beijing 100053, China

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关键词： Drebrin Dendritic spine Synapse Plasticity Cognition function

摘要：

The kinetics of cytoskeletal networks, with actin as a key factor, play a key role in regulating the morphology and function of dendritic spines. Drebrin is a neuron growth and brain development-related actin-binding protein and is present in 70% of the dendritic spines of excitatory synapses. It regulates the development and formation of dendritic spines and well-developed dendritic spines pave the way for presynaptic elements. Well-developed and mature synapses are prerequisite for maintaining nervous system physiology. Abnormal morphology of dendritic spines and loss of synapses are seen in many neurologic diseases associated with cognitive decline. However, the mechanisms governing these pathologic changes and their correlation with drebrin remain unclear. Exploring the relationship between drebrin and cognitive function may provide insight into the early prevention of cognitive impairment and in the diagnosis and treatment of Alzheimer's disease. (C) 2015 Published by Elsevier B.V.

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出版当年[2014]版：

大类 | 3 区医学

小类 | 2 区医学实验技术

最新[2023]版：

大类 | 3 区医学

小类 | 3 区医学实验技术

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出版当年[2013]版：

Q1 MEDICAL LABORATORY TECHNOLOGY

最新[2023]版：

Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 3.2 最新[2023版] 3.7 最新五年平均 2.764 出版当年[2013版] 2.748 出版当年五年平均 2.85 出版前一年[2012版] 2.824 出版后一年[2014版]

第一作者：

第一作者机构： [a]Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China

通讯作者：

通讯机构： [*1]Department of Geriatrics, XuanWu Hospital, CapitalMedical University, #45 Changchun Street, Xicheng District, Beijing 100053, China [*2]Department of Central Laboratory, XuanWu Hospital, CapitalMedical University, #45 Changchun Street, Xicheng District, Beijing 100053, China.

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