机构：[1]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China,[2]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China,[3]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China,[4]Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China,[5]Beijing Key Laboratory on Parkinson Disease, Beijing, 100053, China,[6]Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China,[7]Department of Neurology and Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 10053, China,神经内科老年医学科首都医科大学宣武医院[8]Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China,[9]Department of Physiology, Capital Medical University, Beijing, 100069, China
Objective To investigate potential mechanisms involving abnormal iron metabolism and related inflammation in Parkinson disease (PD) patients with probable rapid eye movement sleep behavior disorder (PRBD). Methods Total 210 PD patients and 31 controls were consecutively recruited. PD patients were evaluated by RBD Screening Questionnaire (RBDSQ) and classified into PRBD and probable no RBD (NPRBD) groups. Demographics information were recorded and clinical symptoms were evaluated by series of rating scales. Levels of iron and related proteins and inflammatory factors in cerebrospinal fluid (CSF) and serum were detected. Comparisons among control, NPRBD and PRBD groups and correlation analyses between RBDSQ score and levels of above factors were performed. Results (1) The frequency of PRBD in PD patients is 31.90%. (2) PRBD group has longer disease duration, more advanced disease stage, severer motor symptoms and more non-motor symptoms than NPRBD group. (3) In CSF, levels of iron, transferrin, NO and IL-1 beta in PRBD group are prominently increased. RBDSQ score is positively correlated with the levels of iron, transferrin, NO and IL-1 beta in PD group. Iron level is positively correlated with the levels of NO and IL-1 beta in PD group. (4) In serum, transferrin level is prominently decreased in PRBD group. PGE(2) level in PRBD group is drastically enhanced. RBDSQ score exhibits a positive correlation with PGE(2) level in PD group. Conclusions PRBD is common in PD patients. PRBD group has severer motor symptoms and more nonmotor symptoms. Excessive iron in brain resulted from abnormal iron metabolism in central and peripheral systems is correlated with PRBD through neuroinflammation.
基金：
the Beijing Healthcare Research Project (JING-15-2),
the National Key Basic Research Program of China(2011CB504100),
the National Natural Science Foundation of China (81071015, 30770745),
the Natural Science Foundation of Beijing, China(7082032),
the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2013BAI09B03),
the project of Beijing Institute for Brain Disorders(BIBDPXM2013_014226_07_000084),
the High Level Technical Personnel Training Project of Beijing Health System, China (2009-3-26),
the Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality (IDHT20140514),
the Capital Clinical Characteristic Application Research(Z121107001012161),
the Excellent Personnel Training Project of Beijing, China
(20071D0300400076),
the Important National Science & Technology Specific Projects(2011ZX09102-003-01),
the Key Project of National Natural Science Foundation of China (81030062),
the Key Project of Beijing Natural Science Foundation(kz200910025001)
the Basic-Clinical Research Cooperation Funding of Capital Medical University (10JL49, 14JL15, 2015-JL-PT-X04).
第一作者机构：[1]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China,
通讯作者：
通讯机构：[1]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China,[2]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China,[3]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China,[4]Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China,[5]Beijing Key Laboratory on Parkinson Disease, Beijing, 100053, China,
推荐引用方式(GB/T 7714)：
Yang Hu,Shu-Yang Yu,Li-Jun Zuo,et al.Investigation on Abnormal Iron Metabolism and Related Inflammation in Parkinson Disease Patients with Probable RBD[J].PLOS ONE.2015,10(10):e0138997.doi:10.1371/journal.pone.0138997.
APA：
Yang Hu,Shu-Yang Yu,Li-Jun Zuo,Ying-Shan Piao,Chen-Jie Cao...&Wei Zhang.(2015).Investigation on Abnormal Iron Metabolism and Related Inflammation in Parkinson Disease Patients with Probable RBD.PLOS ONE,10,(10)
MLA：
Yang Hu,et al."Investigation on Abnormal Iron Metabolism and Related Inflammation in Parkinson Disease Patients with Probable RBD".PLOS ONE 10..10(2015):e0138997
