机构：[1]Department of Neurology, Center for Neurodegenerative Disease, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing 100050, China[2]China National Clinical Research Center for Neurological Diseases, Beijing 100050, China[3]Parkinson’s Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China[4]Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China老年医学科首都医科大学宣武医院
Cerebello-thalamo-cortical circuit has been indicated important for tremor in Parkinson's disease (PD), but the role of dentate nucleus (DN) in parkinsonian tremor remains unclear. To investigate whether DN plays a role in PD tremor, we recruited 50 PD and 29 age-matched health controls (HC). The patients were divided into tremor-dominant (TD) and non-tremor-dominant (NTD) groups. We collected resting-state fMRIs data for each subject. The bilateral DN was then chosen as the region of interest to examine PD tremor-related network changes, as well as its correlation with tremor severity. Voxel-wise functional connectivity analysis revealed that the bilateral DN had higher connectivity with the bilateral cerebellar anterior lobe, and had lower connectivity with the bilateral prefrontal cortex in TD compared to the HC and NTD groups. Functional connectivity of the bilateral DN with the bilateral cerebellar posterior lobe was also higher in TD than NTD group. Functional connectivity between the bilateral DN and the bilateral cerebellar posterior lobe showed positive correlation with tremor severity, while that between the bilateral DN and the bilateral prefrontal cortex displayed negative correlation. Our study demonstrates higher dentato-cerebellar connectivity and lower dentato-prefrontal connectivity in TD patients, which might be involved in the pathogenesis of PD tremor. And we conclude that DN might be associated with the pathogenesis of PD tremor.
基金：
Beijing Municipal Science and Technology Commission, China (Grant No. Z111107058811012),
High Level Technical Personnel Training Project of Beijing Health System, China (Grant No. 2011-3-022),
Beijing Nature Science Foundation and Beijing Municipal Commission of Education, China (Grant No.kz20120025028),
National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2013BAI09B03),
Beijing Institute for Brain Disorders (BIBDPXM2013_014226_07_000084),
the National Science Foundation of China (Grant Numbers 81271429).
第一作者机构：[1]Department of Neurology, Center for Neurodegenerative Disease, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing 100050, China[2]China National Clinical Research Center for Neurological Diseases, Beijing 100050, China
通讯作者：
通讯机构：[1]Department of Neurology, Center for Neurodegenerative Disease, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing 100050, China[2]China National Clinical Research Center for Neurological Diseases, Beijing 100050, China[3]Parkinson’s Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
推荐引用方式(GB/T 7714)：
Huizi Ma,Huimin Chen,Jinping Fang,et al.Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson's disease[J].JOURNAL OF NEUROLOGY.2015,262(10):2247-2256.doi:10.1007/s00415-015-7835-z.
APA：
Huizi Ma,Huimin Chen,Jinping Fang,Liyan Gao,Lingyan Ma...&Tao Feng.(2015).Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson's disease.JOURNAL OF NEUROLOGY,262,(10)
MLA：
Huizi Ma,et al."Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson's disease".JOURNAL OF NEUROLOGY 262..10(2015):2247-2256
医学