机构：[1]Department of Neurology, Affiliated Hospital of Taishan Medical University, Taian, Shandong Province, China[2]Department of Endocrinology, Affiliated Hospital of Taishan Medical University, Taian, Shandong Province, China[3]Department of Neurology, Shandong Taishan Chronic Disease Hospital, Taian, Shandong Province, China[4]Hypoxia Medical Institute, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院
Hypoxic preconditioning activates endogenous mechanisms that protect against cerebral ischemic and hypoxic injury. To better understand these protective mechanisms, adult rats were housed in a hypoxic environment (8% O-2/92% N-2) for 3 hours, and then in a normal oxygen environment for 12 hours. Their cerebrospinal fluid was obtained to culture cortical neurons from newborn rats for 1 day, and then the neurons were exposed to oxygen-glucose deprivation for 1.5 hours. The cerebrospinal fluid from rats subjected to hypoxic preconditioning reduced oxygen-glucose deprivation-induced injury, increased survival rate, upregulated Bcl-2 expression and downregulated Box expression in the cultured cortical neurons, compared with control. These results indicate that cerebrospinal fluid from rats given hypoxic preconditioning protects against oxygen-glucose deprivation-induced injury by affecting apoptosis-related protein expression in neurons from newborn rats.
基金：
the National Science and Technology Support Program of China, (No. 2013BAI07B01);
the Natural Science Foundation of Shandong Province in China, (No. ZR2012HQ014, ZR2011HM044);
the Open Research Project of Beijing Key Laboratory for Hypoxic Preconditioning and Translational Medicine, (No. 2015DYSY02).
第一作者机构：[1]Department of Neurology, Affiliated Hospital of Taishan Medical University, Taian, Shandong Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Affiliated Hospital of Taishan Medical University, Taian, Shandong Province, China
推荐引用方式(GB/T 7714)：
Yan-bo Zhang,Zheng-dong Guo,Mei-yi Li,et al.Cerebrospinal fluid from rats given hypoxic preconditioning protects neurons from oxygen-glucose deprivation-induced injury[J].NEURAL REGENERATION RESEARCH.2015,10(9):1471-1476.doi:10.4103/1673-5374.165519.
APA：
Yan-bo Zhang,Zheng-dong Guo,Mei-yi Li,Si-jie Li,Jing-zhong Niu...&Guo-wei Lv.(2015).Cerebrospinal fluid from rats given hypoxic preconditioning protects neurons from oxygen-glucose deprivation-induced injury.NEURAL REGENERATION RESEARCH,10,(9)
MLA：
Yan-bo Zhang,et al."Cerebrospinal fluid from rats given hypoxic preconditioning protects neurons from oxygen-glucose deprivation-induced injury".NEURAL REGENERATION RESEARCH 10..9(2015):1471-1476
