机构：[a]Department of Critical Care Medicine, Capital Medical University, ICU Fu Xing Hospital, Beijing 10038, China[b]Department of Critical Care Medicine, Capital Medical University, ICU Beijing Ditan Hospital, Beijing 100015, China[c]Medical Intensive Care Unit, MICU Peking Union Medical College Hospital, Beijing 100730, China[d]Department of Critical Care Medicine, ICU Peking University Third Hospital, Beijing 100191, China[e]Department of Critical Care Medicine, Capital Medical University, ICU Beijing Friendship Hospital, Beijing 100050, China.[f]Department of Critical Care Medicine, ICU China-Japan Friendship Hospital, Beijing 100029, China[g]Department of Critical Care Medicine, ICU The First Affiliated Hospital of General Hospital of People's Liberation Army, Beijing 100048, China[h]Department of Critical Care Medicine, Capital Medical University, ICU Beijing Shijitan Hospital, Beijing 100038, China[i]Department of Critical Care Medicine, ICU The 309th Hospital of Chinese People's Liberation Army, Beijing 100094, China[j]Surgical Intensive Care Unit, Capital Medical University, SICU XuanWu Hospital, Beijing 100053, China首都医科大学宣武医院[k]Department of Critical Care Medicine, Capital Medical University, ICU Beijing Tong Ren Hospital, Beijing 100730, China[l]Department of Critical Care Medicine, Capital Medical University, ICU Beijing Tian Tan Hospital, Beijing 100050, China[m]Department of Critical Care Medicine, ICU Beijing Haidian Hospital, Beijing 100080, China[n]Department of Respiratory, China-Japan Friendship Hospital, Beijing 100029, China[o]Surgical Intensive Care Unit, Capital Medical University, SICU Beijing Chao-Yang Hospital, Beijing 100020, China
Purpose: A proposal was made at the International Consensus Conference to classify weaning of patients in intensive care units from mechanical ventilation into simple, difficult, and prolonged weaning groups based on the difficulty and length of the weaning process. The objective of the present study was to determine the incidence and outcome of weaning according to these new categories. Methods: We examined the weaning of patients in intensive care units from mechanical ventilation in a prospective multicenter cohort study. Results: In total, 343 patients were included in the final analysis. Simple, difficult, and prolonged weaning occurred in 200 (58%), 99 (29%), and 44 (13%) patients, respectively. Hospital mortality rates were higher for patients in the prolonged weaning group than in the simple and difficult weaning groups. Multivariate analysis revealed that a lower Glasgow Coma Scale score (P < .014) and hypercapnia at the beginning of the first spontaneous breathing trial (P = .038) were independent predictors of prolonged weaning. Conclusions: Patients who experienced prolonged weaning had significantly higher mortality rates than patients who experienced either simple or difficult weaning. A lower Glasgow Coma Scale score and hypercapnia at the beginning of the weaning process were independent risk factors for prolonged weaning. (C) 2015 Elsevier Inc. All rights reserved.
基金：
the Research Fund of Capital Medical Development (no. H020920020530).
第一作者机构：[a]Department of Critical Care Medicine, Capital Medical University, ICU Fu Xing Hospital, Beijing 10038, China[b]Department of Critical Care Medicine, Capital Medical University, ICU Beijing Ditan Hospital, Beijing 100015, China
共同第一作者：
通讯作者：
通讯机构：[*1]Fu Xing Hospital, Capital Medical University, No. 20 Fuxingmenwai St, Xicheng District, Beijing 10038, China.
推荐引用方式(GB/T 7714)：
Lin Pu ,Bo Zhu ,Li Jiang ,et al.Weaning critically ill patients from mechanical ventilation: A prospective cohort study[J].JOURNAL OF CRITICAL CARE.2015,30(4):862.e7-13.doi:10.1016/j.jcrc.2015.04.001.
APA：
Lin Pu,,Bo Zhu,,Li Jiang,,Bin Du,,Xi Zhu,...&XiuMing Xi,.(2015).Weaning critically ill patients from mechanical ventilation: A prospective cohort study.JOURNAL OF CRITICAL CARE,30,(4)
MLA：
Lin Pu,,et al."Weaning critically ill patients from mechanical ventilation: A prospective cohort study".JOURNAL OF CRITICAL CARE 30..4(2015):862.e7-13
