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Serum CRP and urinary trypsin inhibitor implicate postoperative cognitive dysfunction especially in elderly patients

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收录情况： ◇ SCIE

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机构： [1]Department of Anesthesiology,Xuanwu Hospital of Capital Medical University, Beijing, China, [2]Department of Neurology,Xuanwu Hospital of Capital Medical University, Beijing, China, [3]Department of Orthopedics, Xuanwu Hospital of Capital Medical University, Beijing, China, [4]Department of Biochemistry and Laboratory, The General Hospital of People’s Liberation Army, Beijing, China

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关键词： POCD inflammatory cytokines elderly urinary trypsin inhibitor

摘要：

Purpose: Postoperative cognitive dysfunction (FOOD) characterized as the decline of memory and executive function after major surgery is not well illustrated. The aim of this study is to discover whether inflammatory cytokines and urinary trypsin inhibitor (uTi) contribute to the development of FOOD. Method: Sixty-three patients undergoing lumber discectomy and 47 age-matched control volunteers were involved in this study. The level of C-reaction protein (CRP) and uTi/urine creatinine (Ucr) was measured by immunoturbidimetry and enzyme-inhibition assay, respectively. Meanwhile, ELISA was involved to detect the level of IL-6, IL-10, MMP-9 in serum. Montreal Cognitive Assessment (MoCA) test was used to determine the cognitive decline of the patients and age-matched controls. Result: In FOOD group, the level of IL-6, IL-10, CRP, MMP-9 in serum and uTi/Ucr in urine was significantly higher than that in the group without FOOD. The FOOD was more frequently observed in elderly group than in the middle-aged group (43.75% versus 19.35%, p = 0.038). After logistic regression analysis adjusted by the age, only serum CRP at 72 h postoperation and urinary uTi /Ucr at 24 h postoperation were the independent risk factors of FOOD. Conclusion: Age-related increasing proinflammatory postoperation may result in higher occurrence of FOOD in the elderly. Additionally, patients with extremely high concentrations of CRP in serum at 72 h postoperation and uTi /Ucr in urine at 24 h postoperation are more likely to experience FOOD, especially in the elderly.

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出版当年[2014]版：

大类 | 4 区医学

小类 | 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学

JCR分区：

出版当年[2013]版：

Q4 NEUROSCIENCES

最新[2023]版：

Q4 NEUROSCIENCES

影响因子： 1.7 最新[2023版] 2 最新五年平均 1.528 出版当年[2013版] 1.273 出版当年五年平均 1.216 出版前一年[2012版] 1.521 出版后一年[2014版]

第一作者：

第一作者机构： [1]Department of Anesthesiology,Xuanwu Hospital of Capital Medical University, Beijing, China,

通讯作者：

通讯机构： [*1]Department of Anesthesiology, Xuanwu Hospital of Capital Medical University, Changchun Street No. 45, Beijing 100053, China.

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