机构：[a]Center for Neurodegenerative disease, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing 100050, China[b]Department of Neurobiology and Neurology, Xuanwu Hospital, Capital Medical University, #45 Changchun Street, Beijing 100053, China.神经内科首都医科大学宣武医院[c]Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson's Disease of Beijing, #45 Changchun Street, Beijing 100053, China[d]Parkinson's Disease Center, Beijing Institute for Brain Disorders, #10 You'an Men Wai Xi Tou Tiao, Beijing 100069, China[e]China National Clinical Research Center for Neurological Diseases, #6 Tian Tan Xi Li Street, Beijing 100050, China
The clinical heterogeneity of Parkinson's disease (PD) reveals the presence of several PD subtypes. The objectives of this study were to identify PD subtypes using cluster analysis (CA) and to determine the association between the subtypes and the polymorphisms in LRRK2 (G2385R and R1628P) and GBA (L444P) genes. A k-means CA of demographics, disease progression, motor and non-motor symptoms was performed from 1,510 Chinese PD patients from the Chinese National Consortium on Neurodegenerative Diseases. Pearson correlation analysis was performed to eliminate uninformative characteristics. Blood samples from 852 patients were obtained for genetic analysis of LRRK2 and GBA. Genotypic associations between various subtypes and genetic variants were examined using chi-square test We identified four different subtypes: subtype I was non-tremor dominant (NTD, n = 469; 31.1%); subtype 2 had a rapid disease progression with late onset (RDP-LO, n = 67; 4.4%); subtype 3 had benign pure motor characteristics (BPM, n = 778; 51.5%) without non-motor disturbances; and subtype 4 was tremor dominant with slow disease progression (TD-SP, n = 196; 13.0%). Subtypes I, 2, and 4 had similar mean age of onset. No associations were identified between polymorphisms in LRRK2 (R1628P) and GBA (L444P) genes and the four subtypes (P > 0.05). (C) 2015 Elsevier B.V. All rights reserved.
基金：
the Ministry of Science and Technology of China (2012AA02A514),
the National Basic Research Development Program of China(2011CB504101),
the Natural Science Foundation of Beijing, China, Science and Technology Project of Beijing, Capital Research of Clinical Features (z111107058811012),
the Beijing High Standard Health Human Resource Cultural Program in Health System(2011-3-022),
a major science and technology project of Beijing education committee(kz20120025028).
第一作者机构：[a]Center for Neurodegenerative disease, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing 100050, China[e]China National Clinical Research Center for Neurological Diseases, #6 Tian Tan Xi Li Street, Beijing 100050, China
通讯作者：
通讯机构：[a]Center for Neurodegenerative disease, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Ling-Yan Ma,Piu Chan,Zhu-Qin Gub ,et al.Heterogeneity among patients with Parkinson's disease: Cluster analysis and genetic association[J].JOURNAL OF THE NEUROLOGICAL SCIENCES.2015,351(1-2):41-45.doi:10.1016/j.jns.2015.02.029.
APA：
Ling-Yan Ma,Piu Chan,Zhu-Qin Gub,,Fang-Fei Li&Tao Feng.(2015).Heterogeneity among patients with Parkinson's disease: Cluster analysis and genetic association.JOURNAL OF THE NEUROLOGICAL SCIENCES,351,(1-2)
MLA：
Ling-Yan Ma,et al."Heterogeneity among patients with Parkinson's disease: Cluster analysis and genetic association".JOURNAL OF THE NEUROLOGICAL SCIENCES 351..1-2(2015):41-45
