机构：[1]Departments of Neurology,Beijing Tiantan Hospital, Capital Medical University, Beijing[2]Departments of Geriatrics,Beijing Tiantan Hospital, Capital Medical University, Beijing[3]Core Laboratory for Clinical Medical Research , Beijing Tiantan Hospital, Capital Medical University, Beijing[4]China National Clinical Research Center for Neurological Diseases, Beijing[5]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders,Beijing[6]Beijing Key Laboratory on Parkinson Disease,Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing老年医学科首都医科大学宣武医院[7]Department of Neurology and Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing神经内科老年医学科首都医科大学宣武医院[8]Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai[9]Department of Physiology, Capital Medical University, Beijing, China.
Objectives:To investigate clinical features and potential mechanisms involving -synuclein oligomer and inflammation in patients with Parkinson disease (PD) and probable REM sleep behavior disorder (PRBD).Methods:We used the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) to evaluate patients with PD and classified each as PRBD or not probable (NPRBD). Data collection included demographic information and evaluation of clinical symptoms using a series of rating scales. We tested for -synuclein oligomer and inflammatory factors in CSF and serum. Data analyses included comparisons between PRBD and NPRBD groups and correlation analyses among RBDSQ score and levels of the above factors.Results:The frequency of PRBD in patients with PD was 30.67%. The PRBD group had longer disease duration, more advanced disease stage, more severe motor symptoms, and other more severe nonmotor symptoms, including depression, anxiety, and fatigue. Levels of -synuclein oligomer in CSF and serum in the PRBD group were elevated compared with NPRBD and control groups. RBDSQ score was increased with the elevated -synuclein oligomer level in CSF, interleukin 1 and nitric oxide levels in CSF, and prostaglandin E-2 level in serum in the PD group. The level of -synuclein oligomer in CSF was enhanced with the deterioration of motor symptoms, and the elevated levels of interleukin 1, nitric oxide, and tumor necrosis factor in CSF in the PRBD group.Conclusions:PRBD is common in patients with PD, especially those with longer disease duration and more severe motor and nonmotor symptoms. Elevated -synuclein levels in CSF and serum may be correlated with PRBD through inflammation in central and peripheral nervous systems.
基金：
the National Key Basic Research Program of China (2011CB504100),
the National Natural Science Foundation of China (81071015, 30770745),
the Natural Science Foundation of Beijing, China (7082032),
National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2013BAI09B03),
The Project of Beijing Institute for Brain Disorders (BIBD-PXM2013_014226_07_000084),
High Level Technical Personnel Training Project of Beijing Health System, China (2009-3-26),
The Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality (IDHT20140514),
Capital Clinical Characteristic Application Research (Z121107001012161),
Excellent Personnel Training Project of Beijing, China (20071D0300400076),
Important National Science & Technology Specific Projects (2011ZX09102-003-01),
Key Project of National Natural Science Foundation of China (81030062),
Key Project of Beijing Natural Science Foundation (kz200910025001),
Basic-Clinical Research Cooperation Funding of Capital Medical University (10JL49, 14JL15).
第一作者机构：[1]Departments of Neurology,Beijing Tiantan Hospital, Capital Medical University, Beijing
通讯作者：
通讯机构：[1]Departments of Neurology,Beijing Tiantan Hospital, Capital Medical University, Beijing[2]Departments of Geriatrics,Beijing Tiantan Hospital, Capital Medical University, Beijing[4]China National Clinical Research Center for Neurological Diseases, Beijing[5]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders,Beijing[6]Beijing Key Laboratory on Parkinson Disease,Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing
推荐引用方式(GB/T 7714)：
Yang Hu ,Shu-Yang Yu ,Li-Jun Zuo ,et al.Parkinson disease with REM sleep behavior disorder Features, alpha-synuclein, and inflammation[J].NEUROLOGY.2015,84(9):888-94.doi:10.1212/WNL.0000000000001308.
APA：
Yang Hu,,Shu-Yang Yu,,Li-Jun Zuo,,Chen-Jie Cao,,Fang Wang,...&Wei Zhang,.(2015).Parkinson disease with REM sleep behavior disorder Features, alpha-synuclein, and inflammation.NEUROLOGY,84,(9)
MLA：
Yang Hu,,et al."Parkinson disease with REM sleep behavior disorder Features, alpha-synuclein, and inflammation".NEUROLOGY 84..9(2015):888-94
医学