机构：[1]Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Harbin 150086, Heilongjiang Province, China[2]Department of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China[3]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, People’s Republic of China神经外科首都医科大学宣武医院
The objective of this study is to explore the expression pattern, prognostic value, and functional role of RAB34 in gliomas. RAB34 messenger RNA (mRNA) expression was evaluated from low grade to high grade in 220 glioma patients of the Chinese Glioma Genome Atlas (CGGA). We therefore analyzed RAB34 mRNA expression in two validated datasets. For detecting the protein expression level of RAB34, another 104 glioma tissues were stained by immunohistochemistry. Gene ontology (GO) analysis and gene set variation analysis (GSVA) were used for functional annotation of RAB34. The mRNA and protein expression levels of RAB34 were both related to glioma grade progression and were inversely correlated with overall survival (OS) in high-grade glioma patients. GO analysis and GSVA showed that RAB34 sets related to migration were significantly enriched in the cases with RAB34 high expression. Pearson correlation analysis identified that genes including MMP-11, HSPB1, IGFBP2, HSPA6, IGFBP5, and MMP19 were positively correlated with RAB34. The expression of RAB34 is related to glioma grade progression and confers a poor prognosis in high-grade glioma patients.
基金：
the National High Technology Research and Development Program (No.2012AA02A508),
International Science and Technology Cooperation Program (No. 2012DFA30470),
National 973 Program (No.2011CB707804),
National Natural Science Foundation of China (No. 81201993).
第一作者机构：[1]Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Harbin 150086, Heilongjiang Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Harbin 150086, Heilongjiang Province, China
推荐引用方式(GB/T 7714)：
Hong-jun Wang,Yang Gao,Ling Chen,et al.RAB34 was a progression- and prognosis-associated biomarker in gliomas[J].TUMOR BIOLOGY.2015,36(3):1573-1578.doi:10.1007/s13277-014-2732-0.
APA：
Hong-jun Wang,Yang Gao,Ling Chen,Yong-li Li&Chuan-lu Jiang.(2015).RAB34 was a progression- and prognosis-associated biomarker in gliomas.TUMOR BIOLOGY,36,(3)
MLA：
Hong-jun Wang,et al."RAB34 was a progression- and prognosis-associated biomarker in gliomas".TUMOR BIOLOGY 36..3(2015):1573-1578
