机构：[1]Clinical College of Integrative Medicine, Anhui University of Chinese Medicine, 103 Meishan Road, Hefei 230038, Anhui Province, People’s Republic of China[2]Department of Pharmacology, Xuan Wu Hospital of Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, 45 Changchun Street, Beijing 100053, People’s Republic of China神经变性病教育部重点实验室首都医科大学宣武医院
The cuprizone (CPZ)-induced toxic demyelinating model, characterized by the degeneration of oligodendrocytes, has been utilized to study multiple sclerosis-related lesions. The present study was designed to determine the effect of epimedium flavonoids (EF), the main component extracted from Epimedium sagittatum, on CPZ-induced neuropathological changes in the corpus callosum of C57BL/6 mice. Once we determined an EF-based protective effect on the corpus callosum, we sought to explore the underlying mechanism of this protection. To induce demyelination, 8-week-old mice were fed with 0.2 % CPZ for a maximum period of 6 weeks. EF treatment for a period of 3 weeks effectively decreased the breakdown of myelin, OL loss, and oligodendrocyte precursor cell accumulation in CPZ-fed mice. In addition, EF administration significantly increased the cortical expression level of insulin-like growth factor 1 (IGF-1). This study provides the first in vivo evidence of EF-based protection against CPZ-induced neuropathological changes. Furthermore, our study suggests that upregulated IGF-1 may play a role in this protection.
基金：
the National Natural Science Foundation of China (Nos. 81001656, 81341088),
Beijing Nova Star Program in Science and Technology (No.Z12111000250000),
Capital Medical Development Special Program(No. 2011-1001-06),
the Beijing Organization Department of the Municipal Party Committee Project for Highly Talented Men(2012D005018000010).
第一作者机构：[1]Clinical College of Integrative Medicine, Anhui University of Chinese Medicine, 103 Meishan Road, Hefei 230038, Anhui Province, People’s Republic of China[2]Department of Pharmacology, Xuan Wu Hospital of Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, 45 Changchun Street, Beijing 100053, People’s Republic of China
通讯作者：
通讯机构：[1]Clinical College of Integrative Medicine, Anhui University of Chinese Medicine, 103 Meishan Road, Hefei 230038, Anhui Province, People’s Republic of China[2]Department of Pharmacology, Xuan Wu Hospital of Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, 45 Changchun Street, Beijing 100053, People’s Republic of China
推荐引用方式(GB/T 7714)：
Mengru Liang,Yongyan Chen,Li Zhang,et al.Epimedium Flavonoids Ameliorate Neuropathological Changes and Increases IGF-1 Expression in C57BL/6 Mice Exposed to Cuprizone[J].NEUROCHEMICAL RESEARCH.2015,40(3):492-500.doi:10.1007/s11064-014-1490-0.
APA：
Mengru Liang,Yongyan Chen,Li Zhang,Lin Li,Guangliang Chen&Linlin Yin.(2015).Epimedium Flavonoids Ameliorate Neuropathological Changes and Increases IGF-1 Expression in C57BL/6 Mice Exposed to Cuprizone.NEUROCHEMICAL RESEARCH,40,(3)
MLA：
Mengru Liang,et al."Epimedium Flavonoids Ameliorate Neuropathological Changes and Increases IGF-1 Expression in C57BL/6 Mice Exposed to Cuprizone".NEUROCHEMICAL RESEARCH 40..3(2015):492-500
