机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China神经内科首都医科大学宣武医院[2]Department of Physiology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, Youanmen, Fengtai District, Beijing 100069, China[3]Department of Pharmacology, XuanWu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China首都医科大学宣武医院[4]Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, Beijing 100053, China
Increasing evidences suggested the association between leptin and cognitive functions. Estrogen is an important factor that regulates the production and metabolism of leptin. However, little is known about the relationship between leptin and estrogen in mild cognitive impairment (MCI). Plasma levels of leptin, total estradiol, and beta-amyloid protein (A beta) were measured in a total of 23 female amnestic MCI (aMCI) patients and 19 female cognitively normal controls. This study showed that female aMCI patients had lower plasma levels of leptin and higher levels of estradiol compared to female normal controls. Leptin and estradiol levels were not correlated with cognitive performances or plasma A beta levels in either aMCI patients or normal controls. There was a significant negative correlation between leptin and estrogen in female aMCI patients (r = -0.633, p = 0.002) but not in female normal controls. The potential mechanisms of this disease-stage-specific association between leptin and estrogen need further investigations.
基金：
国家自然科学基金
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|3 区病理学4 区生物工程与应用微生物4 区遗传学4 区医学：研究与实验
最新[2023]版：
无
JCR分区：
出版当年[2013]版：
Q2PATHOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTALQ2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3GENETICS & HEREDITY
第一作者机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Yi Xing ,Jianghong Liu ,Jingdong Xu ,et al.Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment[J].DISEASE MARKERS.2015,2015:doi:10.1155/2015/450237.
APA：
Yi Xing,,Jianghong Liu,,Jingdong Xu,,Linlin Yin,,LinWang,...&Jianping Jia.(2015).Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment.DISEASE MARKERS,2015,
MLA：
Yi Xing,,et al."Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment".DISEASE MARKERS 2015.(2015)
