机构：[1]Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, 45 Changchun Street, Beijing 100053, China首都医科大学?脑血管病研究所首都医科大学宣武医院[2]Department of Traditional Chinese Medicine, Xuanwu Hospital, Capital Medical University, Ministry of Education, 45 Changchun Street, Beijing 100053, China首都医科大学宣武医院[3]Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China[4]Key Laboratory of Neurodegenerative Diseases (Capital Medical University), Ministry of Education, 45 Changchun Street, Beijing 100053, China[5]Department of Neurology, Xuanwu Hospital, Capital Medical University, Ministry of Education, 45 Changchun Street, Beijing 100053, China神经内科首都医科大学宣武医院
Luoyutong (LYT) capsule has been used to treat cerebrovascular diseases clinically in China and is now patented and approved by the State Food and Drug Administration. In this retrospective validation study we investigated the ability of LYT to protect against cerebral ischemia-reperfusion injury in rats. Cerebral ischemia-reperfusion injury was induced by middle cerebral artery occlusion followed by reperfusion. Capsule containing LYT(high dose and mediumdose) as treatment group and Citicoline Sodium as positive control treatment group were administered daily to rats 30 min after reperfusion. Treatment was continued for either 3 days or 14 days. A saline solution was administered to control animals. Behavior tests were performed after 3 and 14 days of treatment. Our findings revealed that LYT treatment improved the neurological outcome, decreased cerebral infarction volume, and reduced apoptosis. Additionally, LYT improved neural plasticity, as the expression of synaptophysin, microtubule associated protein, and myelin basic protein was upregulated by LYT treatment, while neurofilament 200 expression was reduced. Moreover, levels of brain derived neurotrophic factor and basic fibroblast growth factor were increased. Our results suggest that LYT treatment may protect against ischemic injury and improve neural plasticity.
基金：
Projects of Beijing Nova Program(Grant no. Z151100000315065)
Chinese Natural Science Foundation grants (Grant nos. 81271461, 81571280, and 81325007).
第一作者机构：[1]Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, 45 Changchun Street, Beijing 100053, China[2]Department of Traditional Chinese Medicine, Xuanwu Hospital, Capital Medical University, Ministry of Education, 45 Changchun Street, Beijing 100053, China
通讯作者：
通讯机构：[1]Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, 45 Changchun Street, Beijing 100053, China[4]Key Laboratory of Neurodegenerative Diseases (Capital Medical University), Ministry of Education, 45 Changchun Street, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Ning-qun Wang ,Li-yeWang ,Hai-ping Zhao ,et al.Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2015,2015:doi:10.1155/2015/369021.
APA：
Ning-qun Wang,,Li-yeWang,,Hai-ping Zhao,,Ping Liu,,Rong-liang Wang,...&Yu-min Luo.(2015).Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2015,
MLA：
Ning-qun Wang,,et al."Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2015.(2015)
