机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100069, China[3]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China[4]Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing 100053, China
Sex differences in neuropsychiatric symptoms of Alzheimer's disease (AD) have been demonstrated in previous studies, and apolipoprotein E (ApoE) epsilon 4 status influences psychiatric manifestations of AD. However, whether ApoE epsilon 4 status modifies the sex differences in neuropsychiatric symptoms of AD is still unclear. In this study, sex differences in neuropsychiatric abnormalities were stratified and analyzed by ApoE epsilon 4 status in mild AD and moderate to severe AD separately. The Clinical Dementia Rating (CDR) scale and the Neuropsychiatric Inventory (NPI) were used to assess dementia severity and neuropsychiatric symptoms. No sex differences were found in mild AD. In moderate to severe AD, among. epsilon 4 positive individuals, disinhibition was significantly more prevalent (8.0% in men versus 43.2% in women, p = 0.003) and severer (p = 0.003) in female patients. The frequency (16.0% in men versus 51.4% in women, p = 0.005) and score (p = 0.004) of irritability were of borderline significance after strict Bonferroni correction. In conclusion, this study supported the modifying effect of ApoE epsilon 4 status on sex differences in neuropsychiatric symptoms of AD, and this modifying effect was pronounced in moderate to severe stage of AD. The interaction between gender and ApoE epsilon 4 status should be considered in studies on neuropsychiatric symptoms of AD.
基金：
Specialized Research Fund for the Doctoral Program of Higher Education (20131107120002),
CHINA-CANADA Joint Initiative on Alzheimer’s Disease and Related Disorders (81261120571),
the National 973 Project Grant of China (2011CB504104),
Scientific Promoting Project of Beijing Institute for Brain Disorders (BIBDPXM2014 014226 000016),
Seed Grant of International Alliance of Translational Neuroscience(PXM2014 014226 000006),
Key Medical Professional Development Plan of Beijing Municipal Administration of Hospitals (ZYLX201301),
the National Science and Technology Major Projects for “Major New Drug Innovation and Development” of the Twelfth 5-Year Plan Period (2011ZX09307-001-03),
the National Key Technology R&D Program in the Eleventh Five-Year Plan Period(2006BAI02B01),
the Key Project of the National Natural Science Foundation of China (30830045), Beijing Municipal Science & Technology Commission (Z151100004015078),
Beijing Talents Fund (2014000021223ZK31).
第一作者机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing 100053, China[2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100069, China[3]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China[4]Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Yi Xing ,Yi Tang ,Jianping Jia.Sex Differences in Neuropsychiatric Symptoms of Alzheimer's Disease: The Modifying Effect of Apolipoprotein E epsilon 4 Status[J].BEHAVIOURAL NEUROLOGY.2015,2015:doi:10.1155/2015/275256.
APA：
Yi Xing,,Yi Tang,&Jianping Jia.(2015).Sex Differences in Neuropsychiatric Symptoms of Alzheimer's Disease: The Modifying Effect of Apolipoprotein E epsilon 4 Status.BEHAVIOURAL NEUROLOGY,2015,
MLA：
Yi Xing,,et al."Sex Differences in Neuropsychiatric Symptoms of Alzheimer's Disease: The Modifying Effect of Apolipoprotein E epsilon 4 Status".BEHAVIOURAL NEUROLOGY 2015.(2015)
