机构：[1]Central Laboratory, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing Geriatric Medical Research Center, No. 45 Changchun Street, Xicheng District, Beijing 100053, China首都医科大学宣武医院[2]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China[3]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
Dietary composition may influence neuronal function as well as processes underlying synaptic plasticity. In this study, we aimed to determine the effect of high and low caloric diets on a mouse model of learning and memory and to explore mechanisms underlying this process. Mice were divided into three different dietary groups: normal control (n = 12), high-caloric (HC) diet (n = 12), and low-caloric (LC) diet (n = 12). After 6 months, mice were evaluated on the Morris water maze to assess spatial memory ability. We found that HC diet impaired learning and memory function relative to both control and LC diet. The levels of SIRT1 as well as its downstream effectors p53, p16, and peroxisome proliferator-activated receptor gamma (PPAR gamma) were decreased in brain tissues obtained from HC mice. LC upregulated SIRT1 but downregulated p53, p16, and PPAR gamma. The expressions of PI3K and Akt were not altered after HC or LC diet treatment, but both LC and HC elevated the levels of phosphorylated-cAMP response element-binding protein (p-CREB) and IGF-1 in hippocampal CA1 region. Therefore, HC diet-induced dysfunction in learning and memory may be prevented by caloric restriction via regulation of the SIRT1-p53 or IGF-1 signaling pathways and phosphorylation of CREB.
基金：
Beijing Natural Science Foundation (Grant No. 7132044),
Capital Health Development Research Fund (Grant No. 2011-1001-02),
Beijing Health Systems, Health and Technical Personnel of High-level Plan(Grant No. 2009-3-64).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|3 区生物
小类|3 区生物工程与应用微生物3 区医学：研究与实验
最新[2023]版：
无
JCR分区：
出版当年[2013]版：
Q4BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Central Laboratory, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing Geriatric Medical Research Center, No. 45 Changchun Street, Xicheng District, Beijing 100053, China[2]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China
通讯作者：
通讯机构：[1]Central Laboratory, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing Geriatric Medical Research Center, No. 45 Changchun Street, Xicheng District, Beijing 100053, China[3]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
推荐引用方式(GB/T 7714)：
Bao-Lei Xu ,Rong Wang ,Li-NaMa ,et al.Effects of Caloric Intake on Learning and Memory Function in Juvenile C57BL/6J Mice[J].BIOMED RESEARCH INTERNATIONAL.2015,2015:-.doi:10.1155/2015/759803.
APA：
Bao-Lei Xu,,Rong Wang,,Li-NaMa,,Wen Dong,,Zhi-Wei Zhao,...&Xu Zhang.(2015).Effects of Caloric Intake on Learning and Memory Function in Juvenile C57BL/6J Mice.BIOMED RESEARCH INTERNATIONAL,2015,
MLA：
Bao-Lei Xu,,et al."Effects of Caloric Intake on Learning and Memory Function in Juvenile C57BL/6J Mice".BIOMED RESEARCH INTERNATIONAL 2015.(2015):-
