机构：[1]Emergency Department, Xuan Wu Hospital, Capital Medical University, Beijing, China急诊科首都医科大学宣武医院[2]Institute of Hypoxia Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院低氧医学研究室[3]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, USA[4]Vascular Ultrasound Division, Xuan Wu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院血管超声科[5]Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL, USA[6]Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院
Previous studies have indicated a neuroprotective effect of remote limb ischemic preconditioning. The aim of the present study was to assess whether upper arm ischemic preconditioning is feasible and safe in patients with unilateral middle cerebral artery (MCA) stenosis compared to healthy volunteers. Ten patients with unilateral MCA stenosis and 24 healthy volunteers underwent limb ischemic preconditioning, consisting of five cycles of 5-min inflations of a blood pressure cuff to 200 mmHg around an upper limb followed by 5 mm of reperfusion. Limb ischemic preconditioning has no significant effect on the heart rate, oxygenation index, or mean flow velocity in patients with unilateral MCA stenosis or healthy volunteers. However, healthy volunteers showed a reduction in blood pressure 30 min following reperfusion of the last cycle. Limb ischemic preconditioning was found to be safe and well tolerated in both patients and healthy volunteers. We highlight the potential of limb ischemic preconditioning as an adjunct to neuroprotective treatment.
基金：
the National Science Foundation for Distinguished Young Scholars of China (No. 81325007)
the National Natural Science Foundation of China (No. 81160244).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|2 区医学
小类|2 区移植3 区细胞与组织工程3 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|4 区细胞与组织工程4 区医学：研究与实验4 区移植
JCR分区：
出版当年[2013]版：
Q1TRANSPLANTATIONQ2CELL & TISSUE ENGINEERINGQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2TRANSPLANTATIONQ3CELL & TISSUE ENGINEERING
Sijie Li ,Chun Ma ,Guo Shao ,et al.Safety and Feasibility of Remote Limb Ischemic Preconditioning in Patients With Unilateral Middle Cerebral Artery Stenosis and Healthy Volunteers[J].CELL TRANSPLANTATION.2015,24(9):1901-1911.doi:10.3727/096368914X683520.
APA：
Sijie Li,,Chun Ma,,Guo Shao,,Fatema Esmail,,Yang Hua,...&Xunming Ji.(2015).Safety and Feasibility of Remote Limb Ischemic Preconditioning in Patients With Unilateral Middle Cerebral Artery Stenosis and Healthy Volunteers.CELL TRANSPLANTATION,24,(9)
MLA：
Sijie Li,,et al."Safety and Feasibility of Remote Limb Ischemic Preconditioning in Patients With Unilateral Middle Cerebral Artery Stenosis and Healthy Volunteers".CELL TRANSPLANTATION 24..9(2015):1901-1911
