Association of suboptimal health status with psychosocial stress, plasma cortisol and mRNA expression of glucocorticoid receptor alpha/beta in lymphocyte
机构：[1]Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China,[2]Municipal Key Laboratory of Clinical Epidemiology, Beijing, China,[3]Health Medical Examination Center, Xuanwu Hospital, Capital Medical University, Beijing, China, and首都医科大学宣武医院[4]Postgraduate Medicine, School of Medical Sciences, Edith Cowan University, Perth, Australia
Suboptimal health status (SHS) has become a new public health challenge in China. This study investigated whether high SHS is associated with psychosocial stress, changes in cortisol level and/or glucocorticoid receptor (GR) isoform expression. Three-hundred eighty-six workers employed in three companies in Beijing were recruited. The SHS score was derived from data collection in the SHS questionnaire (SHSQ-25). The short standard version of the Copenhagen Psychosocial Questionnaire (COPSOQ) was used to assess job-related psychosocial stress. The mean value of the five scales of COPSOQ and distribution of plasma cortisol and mRNA expression of GR alpha/GR beta between the high level of SHS group and the low level of SHS group were compared using a general linear model procedure. Multiple linear regression analysis was used to analyze the effect of psychosocial stress on SHS. We identified three factors that were predictive of SHS, including "demands at work'', "interpersonal relations and leadership'' and "insecurity at work''. Significantly higher levels of plasma cortisol and GR beta/GR alpha mRNA ratio were observed among the high SHS group. High level of SHS is associated with decreased mRNA expression of GR alpha. This study confirmed the association between chronic psychosocial stress and SHS, indicating that improving the psychosocial work environment may reduce SHS and then prevent chronic diseases effectively.
基金：
National Natural Science
Foundation (81102208, 81273170 and 30771193), the Beijing
Natural Science Foundation (7133229), the National Science
and Technology Support Program (2012BAI37B03), the
Importation and Development of High-Caliber Talents
Project of Beijing Municipal Institutions
(CIT&TCD201304181), Mason Foundation National
Medical Program–ANZ–Australia (CT21946), the Australia-
China Science and Research Fund (ACSRF06444), the
National ECU Industry Collaboration Scheme 2013
(G1001368) and Beijing Municipal Key Laboratory of
Clinical Epidemiology Fund Project (2012LCLB01).
第一作者机构：[1]Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China,[2]Municipal Key Laboratory of Clinical Epidemiology, Beijing, China,
通讯作者：
通讯机构：[*1]Physical Examination Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.[*2]Postgraduate Medicine, School of Medical Sciences, Edith Cowan University, Perth, WA 6027, Australia.
推荐引用方式(GB/T 7714)：
Yu-Xiang Yan,Jing Dong,You-Qin Liu,et al.Association of suboptimal health status with psychosocial stress, plasma cortisol and mRNA expression of glucocorticoid receptor alpha/beta in lymphocyte[J].STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS.2015,18(1):29-34.doi:10.3109/10253890.2014.999233.
APA：
Yu-Xiang Yan,Jing Dong,You-Qin Liu,Jie Zhang,Man-Shu Song...&Wei Wang.(2015).Association of suboptimal health status with psychosocial stress, plasma cortisol and mRNA expression of glucocorticoid receptor alpha/beta in lymphocyte.STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS,18,(1)
MLA：
Yu-Xiang Yan,et al."Association of suboptimal health status with psychosocial stress, plasma cortisol and mRNA expression of glucocorticoid receptor alpha/beta in lymphocyte".STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 18..1(2015):29-34
