机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, China老年医学科首都医科大学宣武医院[2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China[3]Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China[4]Center for Translational Medicine, Guangxi Medical University, Nanning, China[5]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hosptial, Capital Medical University, Beijing, China老年医学科首都医科大学宣武医院[6]Department of Hematology, Second Hospital of Shandong University, Jinan, China
Autologous dopamine (DA) neurons are a new cell source for replacement therapy of Parkinson's disease (PD). In this study, we tested the safety and efficacy of autologous induced pluripotent stem cell (iPSC)-derived DA cells for treatment of a cynomolgus monkey PD model. Monkey bone marrow mesenchymal cells were isolated and induced to iPSCs, followed by differentiation into DA cells using a method with high efficiency. Autologous DA cells were introduced into the brain of a cynomolgus monkey PD model without immunosuppression; three PD monkeys that had received no grafts served as controls. The PD monkey that had received autologous grafts experienced behavioral improvement compared with that of controls. Histological analysis revealed no overgrowth of grafts and a significant number of surviving A9 region-specific graft-derived DA neurons. The study provided a proof-of-principle to employ iPSC-derived autologous DA cells for PD treatment using a nonhuman primate PD model.
基金：
the National Basic Research Program of China (2011CB965103 and 2012CBA01307),
National Natural Science Foundation of China (81422014,31340075 and 31070946),
Sino-German joint fund, Beijing Municipal Natural Science Foundation (5142005),
Technology Foundation for Selected Overseas Chinese,MOHRSS (2014),
Guangxi Natural Science Foundation (2013GXNSFCA019015).
第一作者机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, China[2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China[3]Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, China[2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China[3]Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Shuyan Wang,Chunlin Zou,Linlin Fu,et al.Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson's disease model[J].CELL DISCOVERY.2015,1:doi:10.1038/celldisc.2015.12.
APA：
Shuyan Wang,Chunlin Zou,Linlin Fu,Bin Wang,Jing An...&Zhiguo Chen.(2015).Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson's disease model.CELL DISCOVERY,1,
MLA：
Shuyan Wang,et al."Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson's disease model".CELL DISCOVERY 1.(2015)
