机构：[1]Department of Functional Neurosurgery, Xi’an Red Cross Hospital, Xi’an, Shaanxi Province, China[2]Department of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China康复医学科首都医科大学宣武医院
The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after fluid percussion injury Diazepam can inhibit the hyperexcitability of rat hippocampal neurons after injury, but the mechanism by which it affects excitatory synaptic transmission remains poorly understood. Our results showed that diazepam treatment significantly increased the slope of input-output curves in rat neurons after fluid percussion injury. Diazepam significantly decreased the numbers of spikes evoked by super stimuli in the presence of 15 mu mol/L bicuculline, indicating the existence of inhibitory pathways in the injured rat hippocampus. Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release. These data suggest that diazepam could decrease the fluid percussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area.
基金：
the National Natural Science Foundation of China, (No.81201984);
the Scientific Research Project of Shaanxi Provincial Health Department in China, (No.2010E03);
the Yulin Municipal Science and Technology Research and Development Project, (No.Sf12-06).
第一作者机构：[1]Department of Functional Neurosurgery, Xi’an Red Cross Hospital, Xi’an, Shaanxi Province, China[2]Department of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*1]Department of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China,
推荐引用方式(GB/T 7714)：
Lei Cao,Xiaohua Bie,Su Huo,et al.Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury[J].NEURAL REGENERATION RESEARCH.2014,9(21):1897-·1901.doi:10.4103/1673-5374.145357.
APA：
Lei Cao,Xiaohua Bie,Su Huo,Jubao Du,Lin Liu&Weiqun Song.(2014).Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury.NEURAL REGENERATION RESEARCH,9,(21)
MLA：
Lei Cao,et al."Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury".NEURAL REGENERATION RESEARCH 9..21(2014):1897-·1901
