Longitudinal Changes in Total, 2-LTR Circular, and Integrated HIV-1 DNA During the First Year of HIV-1 Infection in CD4(Low) and CD4(High) Patient Groups with HIV-1 Subtype AE
机构：[1]Infection Department, Beijing You’an Hospital, Capital Medical University, Beijing, China.[2]Dermatological Department, Xuanwu Hospital, Capital Medical University, Beijing, China.首都医科大学宣武医院[3]Dermatological Department, Beijing Huairou Hospital, Beijing, China.[4]MOH Key Laboratory of Systems Biology of Pathogens and AIDS Research Center, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
The level of viral DNA in early HIV-1 infection is an important parameter in the prediction of disease progression. Few data have been published on the dynamics of HIV-1 DNA during the first year of HIV infection. In this study, two distinct HIV-1 patient groups were enrolled. Group 1 (CD4(High) group) maintained their CD4 above 450 cells/mu L within 1 year, while Group 2 (CD4(Low) group) progressed to CD4 below 300 cells/mu L. The amounts of total, 2-long terminal repeat (2-LTR) circular, and integrated HIV-1 DNA were determined in the peripheral blood mononuclear cells at 1, 3, 6, and 12 months after HIV infection. Reductions in the amount of total and integrated HIV-1 DNA were detected in the CD4(High) group during the first year of HIV infection but not in the CD4(Low) group. Disease progression may be related to the body's ability to control HIV-1 DNA during early HIV-1 infection.
基金：
the National Natural
Science Foundation of China (81101250, 81371803), the
National 12th Five-Year Major Projects of China
(2012ZX10001-003, 2012ZX10001-006), Capital Health
research and development special fund (2011-2018-01),
Beijing Natural Science Foundation (7132108), High-level
Health Personnel Training Program of Beijing Health System
(2013-3-072), and Development and Application Research
of Beijing AIDS Clinical Data and Sample Repository
(D131100005313005).
第一作者机构：[1]Infection Department, Beijing You’an Hospital, Capital Medical University, Beijing, China.[2]Dermatological Department, Xuanwu Hospital, Capital Medical University, Beijing, China.[3]Dermatological Department, Beijing Huairou Hospital, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[*1]Infection Department Beijing You’an Hospital Capital Medical University Beijing 100069 China[*2]Dermatological Department Xuanwu Hospital Capital Medical University Beijing 100069 China
推荐引用方式(GB/T 7714)：
Haihong Zhang ,Yanmei Jiao ,Hongjun Li ,et al.Longitudinal Changes in Total, 2-LTR Circular, and Integrated HIV-1 DNA During the First Year of HIV-1 Infection in CD4(Low) and CD4(High) Patient Groups with HIV-1 Subtype AE[J].VIRAL IMMUNOLOGY.2014,27(9):478-482.doi:10.1089/vim.2014.0064.
APA：
Haihong Zhang,,Yanmei Jiao,,Hongjun Li,,Weijun Zhu,,Wei Li,...&Hao Wu.(2014).Longitudinal Changes in Total, 2-LTR Circular, and Integrated HIV-1 DNA During the First Year of HIV-1 Infection in CD4(Low) and CD4(High) Patient Groups with HIV-1 Subtype AE.VIRAL IMMUNOLOGY,27,(9)
MLA：
Haihong Zhang,,et al."Longitudinal Changes in Total, 2-LTR Circular, and Integrated HIV-1 DNA During the First Year of HIV-1 Infection in CD4(Low) and CD4(High) Patient Groups with HIV-1 Subtype AE".VIRAL IMMUNOLOGY 27..9(2014):478-482
