机构：[1]Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China心脏科（内科专业）首都医科大学宣武医院[2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China神经内科神经变性病教育部重点实验室首都医科大学宣武医院
The purpose of this study was to investigate whether common polymorphisms in the C-terminus of SCNN1B gene encoding the beta-subunit of epithelial sodium channel are associated with essential hypertension (EH) in Chinese hypertensive families. A total of 433 subjects from 102 EH families were recruited. Biochemical and anthropometric indices and systematic screening of the C-terminus of SCNN1B were performed. Four single nucleotide polymorphisms (SNPs) were found. Homozygotes for the common A allele at rs3743966 had on average a 12.06 mmHg higher SBP and a 7.43 mmHg higher DBP than homozygotes for the rarer T allele. AA + AT genotype of rs3743966 was also found to maybe a risk factor of hypertension by logistic regression and transmission/disequilibrium test. AA + AT genotype of rs3743966 maybe a risk factor of EH. In conclusion, there was a significant association between the rs3743966 SNP in intron 12 and EH in Chinese hypertensive families.
基金：
Capital Medical Development Fund Project (2009-1054)
Beijing Municipal Science and Technology Commission Funded Project(Z101107050210016)
973 Program (2012CB517805).
第一作者机构：[1]Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Yanling Wang,Zhi Liu,Qi Hua,et al.Association of Epithelial Sodium Channel beta-Subunit Common Polymorphism with Essential Hypertension Families in a Chinese Population[J].CELL BIOCHEMISTRY AND BIOPHYSICS.2014,70(2):1277-1282.doi:10.1007/s12013-014-0051-0.
APA：
Yanling Wang,Zhi Liu,Qi Hua,Ying Chen,Yanning Cai&Rongkun Liu.(2014).Association of Epithelial Sodium Channel beta-Subunit Common Polymorphism with Essential Hypertension Families in a Chinese Population.CELL BIOCHEMISTRY AND BIOPHYSICS,70,(2)
MLA：
Yanling Wang,et al."Association of Epithelial Sodium Channel beta-Subunit Common Polymorphism with Essential Hypertension Families in a Chinese Population".CELL BIOCHEMISTRY AND BIOPHYSICS 70..2(2014):1277-1282
