机构：[1]Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA[2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院[3]Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan[4]Laboratory of Molecular Genetics, DISPUTer, School of Medicine and Health Sciences, “G. d ’Annunzio” University, Chieti-Pescara, Italy
Accumulating preclinical evidence suggests the use of amnion as a source of stem cells for investigations of basic science concepts related to developmental cell biology, but also for stem cells' therapeutic applications in treating human disorders. We previously reported isolation of viable rat amniotic fluid-derived stem (AFS) cells. Subsequently, we recently reported the therapeutic benefits of intravenous transplantation of AFS cells in a rodent model of ischemic stroke. Parallel lines of investigations have provided safety and efficacy of stem cell therapy for treating stroke and other neurological disorders. This review article highlights the need for investigations of mechanisms underlying AFS cells' therapeutic benefits and discusses lab-to-clinic translational gating items in an effort to optimize the clinical application of the cell transplantation for stroke.
基金：
National Institutes of Health(1R01NS071956-01A1)
the Department of Defense (W81XWH-11-1-0634)
VA Merit Review
第一作者机构：[1]Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
通讯作者：
通讯机构：[*1]Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA
推荐引用方式(GB/T 7714)：
Naoki Tajiri,Sandra Acosta,Gabriel S. Portillo-Gonzales,et al.Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke[J].FRONTIERS IN CELLULAR NEUROSCIENCE.2014,8(AUG):227.doi:10.3389/fncel.2014.00227.
APA：
Naoki Tajiri,Sandra Acosta,Gabriel S. Portillo-Gonzales,Daniela Aguirre,Stephanny Reyes...&Cesar V. Borlongan.(2014).Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke.FRONTIERS IN CELLULAR NEUROSCIENCE,8,(AUG)
MLA：
Naoki Tajiri,et al."Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke".FRONTIERS IN CELLULAR NEUROSCIENCE 8..AUG(2014):227
