机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China.神经内科首都医科大学宣武医院[2]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China.老年医学科首都医科大学宣武医院[3]Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson’s Disease of Beijing, 45 Changchun Street, Beijing 100053, China
Background: We conducted this study is to investigate the correlation between stereopsis dysfunction and color perception, as well as whether stereopsis impairment is associated with motor dysfunction in patients with Parkinson's disease (PD). Method: Our present study included 45 PD patients and 50 non-PD control patients attending the Movement Disorder Center at Xuanwu Hospital Capital Medical University in Beijing from July 2011 to November 2011. Neurologic evaluations and visual function assessments were conducted, and the results between two groups of patients were compared. Results: We found that the total error scores (TESs) and partial error scores (PESs) for red, green, blue and purple were all significantly higher in PD patients than in control patients. The limited grade on the FLY Stereo Acuity Test with LEA Symbols was significantly lower in PD patients than in control patients (P = 0.0001), whereas the percentage of abnormal stereopsis in PD patients was significantly higher than in control patients (42.2% vs. 12%; P = 0.001). Multiple linear regression analysis showed that PD patients with higher Hoehn and Yahr Scale stage, and those with decreased stereopsis had higher Unified Parkinson's Disease Rating Scale (UPDRS) motor scores and worse motor function. Furthermore, our study demonstrates that the UPDRS motor scores and total average number of the Purdue Pegboard Test scores of PD patients were significantly improved when they had taken their medications, and the TESs and PESs for green were lower in when they were off their medications. Conclusion: Our results provide more information on the underlying mechanisms of vision, motor and stereopsis impairments in PD patients.
基金：
National High Technology Research and Development Program of China (2006AA02A408 and 2012AA02A514)
the Beijing High Standard Health Human Resource Cultural Program in Health System (2009-1-12)
第一作者机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China.[2]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China.
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China.[2]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China.[3]Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson’s Disease of Beijing, 45 Changchun Street, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Liang Sun,Hui Zhang,Zhuqin Gu,et al.Stereopsis impairment is associated with decreased color perception and worse motor performance in Parkinson's disease[J].EUROPEAN JOURNAL OF MEDICAL RESEARCH.2014,19(1):29.doi:10.1186/2047-783X-19-29.
APA：
Liang Sun,Hui Zhang,Zhuqin Gu,Ming Cao,Dawei Li&Piu Chan.(2014).Stereopsis impairment is associated with decreased color perception and worse motor performance in Parkinson's disease.EUROPEAN JOURNAL OF MEDICAL RESEARCH,19,(1)
MLA：
Liang Sun,et al."Stereopsis impairment is associated with decreased color perception and worse motor performance in Parkinson's disease".EUROPEAN JOURNAL OF MEDICAL RESEARCH 19..1(2014):29
