A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: An overview of individual participant data from 32 prospective cohorts from the Asia-Pacific Region
机构：[1]Epidemiology & Biostatistics Division, School of Population Health, University of Queensland, Brisbane, Australia.[2]The George Institute for Global Health, University of Sydney, Sydney, Australia.[3]Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.[4]Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia.[5]School of Public Health/Department of Community Medicine, The University of Hong Kong, Hong Kong, China.[6]George Centre for Healthcare Innovation, University of Oxford, Oxford, UK.[7]Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.[8]Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.[9]Department of Health Science, Shiga University of Medical Science, Shiga, Japan.[10]Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.[11]Department of Epidemiology and Social Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.首都医科大学宣武医院[12]Division of Epidemiology, Johns Hopkins University, Baltimore, USA.
Background: Most of what is known regarding the epidemiology of mortality from heart failure (HF) comes from studies within Western populations with few data available from the Asia-Pacific region where the burden of heart failure is increasing. Methods: Individual level data from 543694 (85% Asian; 36% female) participants from 32 cohorts in the Asia Pacific Cohort Studies Collaboration were included in the analysis. Adjusted hazard ratios (HR) and 95% confidence intervals (CI) for mortality from HF were estimated separately for Asians and non-Asians for a quintet of cardiovascular risk factors: systolic blood pressure, diabetes, body mass index, cigarette smoking and total cholesterol. All analyses were stratified by sex and study. Results: During 3,793,229 person years of follow-up there were 614 HF deaths (80% Asian). The positive associations between elevated blood pressure, obesity, and cigarette smoking were consistent for Asians and non-Asians. There was evidence to indicate that diabetes was a weaker risk factor for death from HF for Asians compared with non-Asians: HR 1.26 (95% CI: 0.74-2.13) versus 3.04 (95% CI 1.76-5.25) respectively; p for interaction = 0.022. Additional adjustment for covariates did not materially change the overall associations. There was no good evidence to indicate that total cholesterol was a risk factor for HF mortality in either population. Conclusions: Most traditional cardiovascular risk factors including elevated blood pressure, obesity and cigarette smoking appear to operate similarly to increase the risk of death from HF in Asians and non-Asians populations alike.
基金：
Australian National Health and Medical Research Council (NHMRC)(grant 571281)
NHMRC fellowship(1020812)
第一作者机构：[1]Epidemiology & Biostatistics Division, School of Population Health, University of Queensland, Brisbane, Australia.
通讯作者：
通讯机构：[1]Epidemiology & Biostatistics Division, School of Population Health, University of Queensland, Brisbane, Australia.
推荐引用方式(GB/T 7714)：
Rachel R Huxley,Federica Barzi,Jean Woo,et al.A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: An overview of individual participant data from 32 prospective cohorts from the Asia-Pacific Region[J].BMC CARDIOVASCULAR DISORDERS.2014,14:doi:10.1186/1471-2261-14-61.
APA：
Rachel R Huxley,Federica Barzi,Jean Woo,Graham Giles,Tai Hing Lam...&Mark Woodward.(2014).A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: An overview of individual participant data from 32 prospective cohorts from the Asia-Pacific Region.BMC CARDIOVASCULAR DISORDERS,14,
MLA：
Rachel R Huxley,et al."A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: An overview of individual participant data from 32 prospective cohorts from the Asia-Pacific Region".BMC CARDIOVASCULAR DISORDERS 14.(2014)
