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Experimental study for the mechanism of gastroesophageal-reflux-associated asthma

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收录情况： ◇ SCIE

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机构： [1]Department of General Surgery,Xuanwu Hospital, Capital Medical University [2]Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, [3]The first Affiliated Hospital of Zhengzhou University [4]China Center for GER, Second Artillery General Hospital, Beijing Normal University, Beijing 100088, China

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关键词： asthma cytokines eosinophil gastroesophageal reflux Interleukin-5

摘要：

Epidemiologic studies have shown a strong association between gastroesophageal reflux (GER) and asthma, especially in children. Diagnosing GER can be difficult in some patients when GER presents solely with asthma. The aim of this study was to explore the relationship between GER and asthma with animal model. Sixty rats were randomly divided into six equal groups, GER group, GER-associated-asthma group, allergic asthma group, and their control groups. The cytokine levels and concentration of inflammatory cells in bronchoalveolar lavage (BAL) were determined. The BAL of the rats with allergic asthma contained higher concentration of Interleukin-5 (IL-5) and more eosinophils than those of rats with GER-associated-asthma. This demonstrates that assaying the concentrations of IL-5 and inflammatory cells in BAL may be an effective method of distinguishing GER-associated asthma from allergic asthma.

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出版当年[2013]版：

大类 | 4 区医学

小类 | 4 区胃肠肝病学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区胃肠肝病学

JCR分区：

出版当年[2012]版：

Q3 GASTROENTEROLOGY & HEPATOLOGY

最新[2023]版：

Q3 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 2.4 最新[2023版] 2.7 最新五年平均 1.642 出版当年[2012版] 1.676 出版当年五年平均 1.814 出版前一年[2011版] 2.057 出版后一年[2013版]

第一作者：

第一作者机构： [2]Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University,

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通讯作者：

通讯机构： [*1]Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, No. 45 ChangChun Street, Xicheng District, Beijing 100053, China.

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