机构：[1]Function Laboratory, Institute of Acu-Mox, China Academy of Chinese Medical Sciences, Beijing 100700, China[2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[3]Institute of Neurosurgery, Tiantan Hospital, Beijing 100050, China
Background Previous studies demonstrated that vagus nerve stimulation (VNS) is an effective therapy for drug-resistant epilepsy. Acupuncture is also used to treat epilepsy. This study was designed to examine the safety and effectiveness of transcutaneous auricular vagus nerve stimulation (ta-VNS) for patients with drug-resistant epilepsy. Methods A total of 50 volunteer patients with drug-resistant epilepsy were selected for a random clinical trial to observe the therapeutic effect of ta-VNS. The seizure frequency, quality of life, and severity were assessed in weeks 8, 16, and 24 of the treatment according to the percentage of seizure frequency reduction. Results In the pilot study, 47 of the 50 epilepsy patients completed the 24-week treatment; three dropped off. After 8-week treatment, six of the 47 patients (12%) were seizure free and 12 (24%) had a reduction in seizure frequency. In week 16 of the continuous treatment, six of the 47 patients (12%) were seizure free; 17 (34%) had a reduction in seizure frequency. After 24 weeks' treatment, eight patients (16%) were seizure free; 19 (38%) had reduced seizure frequency. Conclusion Similar to the therapeutic effect of VNS, ta-VNS can suppress epileptic seizures and is a safe, effective, economical, and widely applicable treatment option for drug-resistant epilepsy. (ChiCTR-TRC-10001023)
基金：
the General Program of National Natural Science Foundation of China (No. 30973798),
the Special Program of Chinese Medicine of the National Basic Research Program of China (973 Program, No. 2012CB518503),
National Twelfth Five-year Science and Technology Support Program (No.2012BAF14B10),
the Capital Medical Development Foundation of China (TCM-SF-2009-II-15).
第一作者机构：[1]Function Laboratory, Institute of Acu-Mox, China Academy of Chinese Medical Sciences, Beijing 100700, China
共同第一作者：
通讯作者：
通讯机构：[1]Function Laboratory, Institute of Acu-Mox, China Academy of Chinese Medical Sciences, Beijing 100700, China
推荐引用方式(GB/T 7714)：
Rong Peijing ,Liu Aihua ,Zhang Jianguo ,et al.An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation[J].CHINESE MEDICAL JOURNAL.2014,127(2):300-304.doi:10.3760/cma.j.issn.0366-6999.20131511.
APA：
Rong Peijing,,Liu Aihua,,Zhang Jianguo,,Wang Yuping,,Yang Anchao,...&Zhu Bing.(2014).An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation.CHINESE MEDICAL JOURNAL,127,(2)
MLA：
Rong Peijing,,et al."An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation".CHINESE MEDICAL JOURNAL 127..2(2014):300-304
