Objective: Recent neuroimaging studies have shown that elderly adults exhibit increased and decreased activation on various cognitive tasks, yet little is known about age-related changes in inductive reasoning. Methods: To investigate the neural basis for the aging effect on inductive reasoning, 15 young and 15 elderly subjects performed numerical inductive reasoning while in a magnetic resonance (MR) scanner. Results: Functional magnetic resonance imaging (fMRI) analysis revealed that numerical inductive reasoning, relative to rest, yielded multiple frontal, temporal, parietal, and some subcortical area activations for both age groups. In addition, the younger participants showed significant regions of task-induced deactivation, while no deactivation occurred in the elderly adults. Direct group comparisons showed that elderly adults exhibited greater activity in regions of task-related activation and areas showing task-induced deactivation (TID) in the younger group. Conclusions: Our findings suggest an age-related deficiency in neural function and resource allocation during inductive reasoning.
基金：
the National Natural Science Foundation of China (61105118),
Beijing Nova Program (No. Z12111000250000, Z131107000413120)
the Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning (CNLZD1302).
第一作者机构：[1]Department of Radiology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[*1]Department of Radiology, Xuan Wu Hospital, Capital Medical University, 45 Chang Chun Street, Xicheng District, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Li Sun ,Peipeng Liang ,Xiuqin Jia ,et al.Age-related increase in brain activity during task-related and -negative networks and numerical inductive reasoning[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY.2014,7(9):5960-U1971.
APA：
Li Sun,,Peipeng Liang,,Xiuqin Jia,,Zhigang Qi,&Kuncheng Li.(2014).Age-related increase in brain activity during task-related and -negative networks and numerical inductive reasoning.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,7,(9)
MLA：
Li Sun,,et al."Age-related increase in brain activity during task-related and -negative networks and numerical inductive reasoning".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7..9(2014):5960-U1971
