机构：[1]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China放射科首都医科大学宣武医院[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China[3]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院
Mildcognitive impairment (MCI) refers to a transitional state between normal aging and dementia and is a syndrome with cognitive decline greater than expected for an individual's age and educational level. As a subtype of MCI, amnestic mild cognitive impairment (aMCI) most often leads to Alzheimer's disease. This study aims to elucidate the altered brain activation in patients with aMCI using resting-state functional magnetic resonance. We observed Frequency-dependent changes in the amplitude of low-frequency fluctuations in aMCI patients (n = 20), and normal subjects (n = 18). At the same time, we took gray matter volume as a covariate. We found that aMCI patients had decreased amplitude of low-frequency fluctuation signal in left superior temporal gyrus, right middle temporal gyrus, right inferior parietal lobe, and right postcentral gyrus compared to the control group. Specially, aMCI patients showed increased signal in left superior and middle frontal gyrus. Our results suggested that increased activation in frontal lobe of aMCI patients may indicate effective recruitment of compensatory brain resources. This finding and interpretation may lead to the better understanding of cognitive changes of aMCI.
基金：
the Natural Science Foundation of China, (Grant nos. 30930029 and 30970823)
语种：
外文
被引次数：
WOS：
PubmedID：
JCR分区：
出版当年[2012]版：
无
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Zhilian Zhao ,Jie Lu ,Xiuqin Jia ,et al.Selective Changes of Resting-State Brain Oscillations in aMCI: An fMRI Study Using ALFF[J].BIOMED RESEARCH INTERNATIONAL.2014,2014(15):doi:10.1155/2014/920902.
APA：
Zhilian Zhao,,Jie Lu,,Xiuqin Jia,,Wang Chao,,Ying Han,...&Kuncheng Li.(2014).Selective Changes of Resting-State Brain Oscillations in aMCI: An fMRI Study Using ALFF.BIOMED RESEARCH INTERNATIONAL,2014,(15)
MLA：
Zhilian Zhao,,et al."Selective Changes of Resting-State Brain Oscillations in aMCI: An fMRI Study Using ALFF".BIOMED RESEARCH INTERNATIONAL 2014..15(2014)
