机构：[1]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China放射科首都医科大学宣武医院[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China[3]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[4]State Key Laboratory for Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
The neuropsychological tests in patients with internal carotid artery (ICA) demonstrated cognitive deficits associated with frontal lobe dysfunction, but the pathophysiological mechanism of memory impairment is not fully understood. This study evaluated relationship between degree of ICA stenosis and frontal activations induced by working memory (WM) task using fMRI. The fMRI data of 21 patients with unilateral ICA stenosis (left/right, 11/10) and 21 controls were analyzed. In comparison with controls, ICA patients demonstrated significant activations in middle frontal gyrus (MFG) bilaterally, particularly in leftMFG. In right ICA stenosis, there was slightly less MFG activation than that of controls. Importantly, lower MFG activity was associated with higher stenosis of ipsilateral ICA. For left ICA stenosis, weaker activation in left MFG was negatively correlated with degree of stenosis. Similarly, for right ICA stenosis, there was a significant negative correlation between right ICA stenosis and weaker activation of right MFG. Cognitive impairments in ICA stenosis were associated with frontal lobe dysfunctions. Left ICA stenosis had worse WMimpairments than right ICA stenosis, which was affected by the degree of stenosis.
语种：
外文
被引次数：
WOS：
PubmedID：
JCR分区：
出版当年[2012]版：
无
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Shasha Zheng ,Miao Zhang ,Xiaoyi Wang ,et al.Functional MRI Study of Working Memory Impairment in Patients with Symptomatic Carotid Artery Disease[J].BIOMED RESEARCH INTERNATIONAL.2014,2014(6):doi:10.1155/2014/327270.
APA：
Shasha Zheng,,Miao Zhang,,Xiaoyi Wang,,Qingfeng Ma,,Hua Shu,...&Kuncheng Li.(2014).Functional MRI Study of Working Memory Impairment in Patients with Symptomatic Carotid Artery Disease.BIOMED RESEARCH INTERNATIONAL,2014,(6)
MLA：
Shasha Zheng,,et al."Functional MRI Study of Working Memory Impairment in Patients with Symptomatic Carotid Artery Disease".BIOMED RESEARCH INTERNATIONAL 2014..6(2014)
