机构:[1]Department of Gastroenterology, Wangjing Hospital of China Academy of Traditional Chinese Medicine, Beijing 100102, China[2]Department of Gastroenterology, Tianjin Nankai Hospital, Tianjin 300100, China[3]Department of Gastroenterology, Xuanwu Hospital of Traditional Chinese Medicine, Beijing 100050, China消化科首都医科大学宣武医院[4]Department of Gastroenterology, Shanghai Seventh People's Hospital, Shanghai 200137, China
OBJECTIVE: To observe the curative effect of a recipe for warming the kidney and fortifying the spleen on diarrhea-predominant irritable bowel syndrome (IBS-D). METHODS: This multi-center, double-blind, randomized, and controlled trial included 240 patients that met the inclusion criterion and were then divided into two groups of 120. Patients in the treatment group (group A) took modified Sishen Wan orally for warming the kidney and fortifying the spleen and patients in the control group (group B) took a placebo, Chao Maiya, for 4 weeks. 28 days after withdrawal, there was a 6-month follow-up to observe patient recurrence condition. The total effective rate, curative effect, and recurrence rate were evaluated after treatment. RESULTS: There was statistical difference (P<0.01) between the two groups in total effective rate (92.24% in the treatment group and 49.07% in the control group), in curative effect of TCM syndrome (90.52% and 47.22%, respectively), and in the recurrence rate (15.79% and 56.86%, respectively) within 6 months after treatment. CONCLUSION: Modified Sishen Wan, for warming the kidney and fortifying the spleen, can effectively treat IBS-D and better control its recurrence. (C) 2013 JTCM. All rights reserved.
基金:
National Natural Science Foundation of China (No. 81072800)
第一作者机构:[1]Department of Gastroenterology, Wangjing Hospital of China Academy of Traditional Chinese Medicine, Beijing 100102, China
通讯作者:
通讯机构:[*1]Department of Gastroenterology, Wangjing Hospital, Beijing 100102, China.
推荐引用方式(GB/T 7714):
Xiaolan Su,Yanping Tang,Jing Zhang,et al.Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome[J].JOURNAL OF TRADITIONAL CHINESE MEDICINE.2013,33(5):615-619.doi:10.1016/S0254-6272(14)60030-3.
APA:
Xiaolan Su,Yanping Tang,Jing Zhang,Yuebin Dong,Wei Wei...&Yong Liu.(2013).Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome.JOURNAL OF TRADITIONAL CHINESE MEDICINE,33,(5)
MLA:
Xiaolan Su,et al."Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome".JOURNAL OF TRADITIONAL CHINESE MEDICINE 33..5(2013):615-619